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Immunogenetics of dermatitis herpetiformis.

Publication ,  Journal Article
Hall, RP; Otley, C
Published in: Semin Dermatol
September 1991

Dermatitis herpetiformis (DH) is a pruritic, papulovesicular skin disease characterized in part by the presence of granular deposits of IgA at the dermal-epidermal junction, an associated gluten sensitive enteropathy (GSE), and a strong association with specific human histocompatibility leukocyte antigens (HLA). Initial investigations revealed that 60% to 70% of patients with DH expressed the HLA antigen B8 (normal subjects = 21%). Further investigation of the HLA associations seen in patients with DH has revealed an even higher frequency of the HLA class II antigens HLA-DR3 (DH = 95%; normal = 23%), HLA-DQw2 (DH = 100%; normal = 40%), and HLA-DPw1 (DH = 42%; normal = 11%). Analysis of the genetic linkage of HLA antigens has revealed that the strongest HLA association in patients with DH is with the HLA class II antigens DR3 and DQw2. This article will discuss current studies regarding the role of HLA associations and DH and the role this strong HLA association may play in the pathophysiology of DH.

Duke Scholars

Published In

Semin Dermatol

ISSN

0278-145X

Publication Date

September 1991

Volume

10

Issue

3

Start / End Page

240 / 245

Location

United States

Related Subject Headings

  • Major Histocompatibility Complex
  • Humans
  • HLA Antigens
  • Dermatitis Herpetiformis
 

Citation

APA
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MLA
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Hall, R. P., & Otley, C. (1991). Immunogenetics of dermatitis herpetiformis. Semin Dermatol, 10(3), 240–245.
Hall, R. P., and C. Otley. “Immunogenetics of dermatitis herpetiformis.Semin Dermatol 10, no. 3 (September 1991): 240–45.
Hall RP, Otley C. Immunogenetics of dermatitis herpetiformis. Semin Dermatol. 1991 Sep;10(3):240–5.
Hall, R. P., and C. Otley. “Immunogenetics of dermatitis herpetiformis.Semin Dermatol, vol. 10, no. 3, Sept. 1991, pp. 240–45.
Hall RP, Otley C. Immunogenetics of dermatitis herpetiformis. Semin Dermatol. 1991 Sep;10(3):240–245.

Published In

Semin Dermatol

ISSN

0278-145X

Publication Date

September 1991

Volume

10

Issue

3

Start / End Page

240 / 245

Location

United States

Related Subject Headings

  • Major Histocompatibility Complex
  • Humans
  • HLA Antigens
  • Dermatitis Herpetiformis