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Alterations in HLA-DP and HLA-DQ antigen frequency in patients with dermatitis herpetiformis.

Publication ,  Journal Article
Hall, RP; Sanders, ME; Duquesnoy, RJ; Katz, SI; Shaw, S
Published in: J Invest Dermatol
October 1989

Dermatitis herpetiformis (DH) is associated with a markedly increased frequency of the HLA class II antigens DR3 and DQw2. To investigate a possible role of HLA-DP (or closely associated genes) in the pathogenesis of DH as well as to confirm the previously described alterations of HLA-DR3 and HLA-DQw2 antigen frequency, we have typed 43 patients with DH for HLA-DP, HLA-DQ, and HLA-DR antigens. All patients with DH had typical clinical and histologic features, as well as granular deposits of IgA at the dermal-epidermal junction by direct immunofluorescence. HLA-DR3 was expressed in 41 of 43 (95%) DH patients, whereas HLA-DQw2 was expressed in all 43 (100%). The overall distribution of HLA-DP antigens in patients with DH was significantly different from that seen in all controls and in HLA-DR3 and HLA-DQw2 controls (p less than 0.02). Examination of the frequency of individual DP antigens revealed that HLA-DPw1 was increased (42% of patients with DH vs 11% of all controls and 26% of DR3 positive controls), but this increase was not statistically greater than that expected due to the disequilibrium linkage of DPw1 with DR3/DQw2. Patients with DH, however, did have a statistically significant decreased frequency of DPw2 (14% of patients vs 31% of all controls and 41% of DR3 positive controls) (pc less than 0.05). Studies of three informative families demonstrated that the DPw2 genes of the DH patients were not present on the haplotype thought to carry a DH susceptibility gene (HLA-A1, HLA-B8, HLA-DR3, HLA-DQw2). A role of HLA-DP region genes in the pathogenesis of DH is further suggested by the observation that HLA-DPw1 was expressed in 82% (9 of 11) of DH patients with IgA antibodies against dietary antigens as compared with only 33% (4 of 12) of patients without IgA antibodies. HLA-DP genes or genes closely linked to them may be important in DH either as markers of the disease haplotype or by direct involvement in its pathogenesis.

Duke Scholars

Published In

J Invest Dermatol

DOI

ISSN

0022-202X

Publication Date

October 1989

Volume

93

Issue

4

Start / End Page

501 / 505

Location

United States

Related Subject Headings

  • Polymorphism, Restriction Fragment Length
  • Phenotype
  • Male
  • Immunoglobulin A
  • Humans
  • Histocompatibility Testing
  • HLA-DR Antigens
  • HLA-DQ Antigens
  • HLA-DP Antigens
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hall, R. P., Sanders, M. E., Duquesnoy, R. J., Katz, S. I., & Shaw, S. (1989). Alterations in HLA-DP and HLA-DQ antigen frequency in patients with dermatitis herpetiformis. J Invest Dermatol, 93(4), 501–505. https://doi.org/10.1111/1523-1747.ep12284056
Hall, R. P., M. E. Sanders, R. J. Duquesnoy, S. I. Katz, and S. Shaw. “Alterations in HLA-DP and HLA-DQ antigen frequency in patients with dermatitis herpetiformis.J Invest Dermatol 93, no. 4 (October 1989): 501–5. https://doi.org/10.1111/1523-1747.ep12284056.
Hall RP, Sanders ME, Duquesnoy RJ, Katz SI, Shaw S. Alterations in HLA-DP and HLA-DQ antigen frequency in patients with dermatitis herpetiformis. J Invest Dermatol. 1989 Oct;93(4):501–5.
Hall, R. P., et al. “Alterations in HLA-DP and HLA-DQ antigen frequency in patients with dermatitis herpetiformis.J Invest Dermatol, vol. 93, no. 4, Oct. 1989, pp. 501–05. Pubmed, doi:10.1111/1523-1747.ep12284056.
Hall RP, Sanders ME, Duquesnoy RJ, Katz SI, Shaw S. Alterations in HLA-DP and HLA-DQ antigen frequency in patients with dermatitis herpetiformis. J Invest Dermatol. 1989 Oct;93(4):501–505.
Journal cover image

Published In

J Invest Dermatol

DOI

ISSN

0022-202X

Publication Date

October 1989

Volume

93

Issue

4

Start / End Page

501 / 505

Location

United States

Related Subject Headings

  • Polymorphism, Restriction Fragment Length
  • Phenotype
  • Male
  • Immunoglobulin A
  • Humans
  • Histocompatibility Testing
  • HLA-DR Antigens
  • HLA-DQ Antigens
  • HLA-DP Antigens
  • Female