Cross-reactive idiotypes in the sera of patients with bullous pemphigoid express anti-basement-membrane-zone activity.
Publication
, Journal Article
Rico, MJ; Hall, RP
Published in: Dermatology
1994
We have previously generated a monoclonal anti-idiotypic antibody (antiId 3-17) specific for a cross-reactive idiotype (CRI) present in sera and bound at the basement membrane zone (BMZ) in some patients with bullous pemphigoid (BP). The purpose of the present study was to determine if CRI isolated from sera of patients with BP expressed anti-BMZ activity. CRI, isolated by affinity chromatography from 5 nonrelated patients with BP, bound to the epidermal side of normal human split skin as detected by indirect immunofluorescence. In patients with BP, the presence of the CRI on circulating IgG is associated with anti-BMZ activity.
Duke Scholars
Published In
Dermatology
DOI
ISSN
1018-8665
Publication Date
1994
Volume
189 Suppl 1
Start / End Page
72 / 75
Location
Switzerland
Related Subject Headings
- Skin
- Pemphigoid, Bullous
- Immunoglobulin G
- Humans
- Epitopes
- Dermatology & Venereal Diseases
- Cross Reactions
- Chromatography, Affinity
- Basement Membrane
- Autoantibodies
Citation
APA
Chicago
ICMJE
MLA
NLM
Rico, M. J., & Hall, R. P. (1994). Cross-reactive idiotypes in the sera of patients with bullous pemphigoid express anti-basement-membrane-zone activity. Dermatology, 189 Suppl 1, 72–75. https://doi.org/10.1159/000246935
Rico, M. J., and R. P. Hall. “Cross-reactive idiotypes in the sera of patients with bullous pemphigoid express anti-basement-membrane-zone activity.” Dermatology 189 Suppl 1 (1994): 72–75. https://doi.org/10.1159/000246935.
Rico MJ, Hall RP. Cross-reactive idiotypes in the sera of patients with bullous pemphigoid express anti-basement-membrane-zone activity. Dermatology. 1994;189 Suppl 1:72–5.
Rico, M. J., and R. P. Hall. “Cross-reactive idiotypes in the sera of patients with bullous pemphigoid express anti-basement-membrane-zone activity.” Dermatology, vol. 189 Suppl 1, 1994, pp. 72–75. Pubmed, doi:10.1159/000246935.
Rico MJ, Hall RP. Cross-reactive idiotypes in the sera of patients with bullous pemphigoid express anti-basement-membrane-zone activity. Dermatology. 1994;189 Suppl 1:72–75.
Published In
Dermatology
DOI
ISSN
1018-8665
Publication Date
1994
Volume
189 Suppl 1
Start / End Page
72 / 75
Location
Switzerland
Related Subject Headings
- Skin
- Pemphigoid, Bullous
- Immunoglobulin G
- Humans
- Epitopes
- Dermatology & Venereal Diseases
- Cross Reactions
- Chromatography, Affinity
- Basement Membrane
- Autoantibodies