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Circulating IgA immune complexes in patients with psoriasis.

Publication ,  Journal Article
Hall, RP; Peck, GL; Lawley, TJ
Published in: J Invest Dermatol
June 1983

The sera of 21 patients with psoriasis were examined for the presence of IgA-containing circulating immune complexes (CIC) using the Raji IgA radioimmunoassay. In addition, the Raji IgG radioimmunoassay and 125I-Clq binding assay were used to detect IgG- and IgM-containing CIC. Twenty-five patients with other hyperkeratotic skin disorders were studied as controls. Patients were studied before institution of systemic therapy with etretinate (20 patients) or 13-cis-retinoic acid (1 patient). In addition, sera of 15 of the patients treated with etretinate were studied before, during, and after therapy. The extent of pretreatment disease involvement as well as response to therapy were evaluated in a blinded fashion. Fourteen of 21 (67%) patients with psoriasis had evidence of IgA-containing CIC at some time during the course of their disease, as compared to only 1 of 25 patients with other hyperkeratotic skin disorders. In contrast, only 2 of 19 (11%) had evidence of IgG-containing CIC using the Raji IgG assay, and only 1 of 19 (5%) had evidence of IgG- or IgM-containing CIC using the 125I-Clq binding assay. A positive correlation was found between the extent of pretreatment disease involvement and the level of IgA-containing CIC by linear regression analysis (p = 0.01). There was, however, no correlation between clinical improvement and the presence or level of IgA-containing CIC in 15 patients followed during therapy. Sucrose density gradient analysis of the IgA-containing CIC found in 2 of these patients demonstrated IgA-containing CIC in the 9S to 13S region. The finding of IgA-containing CIC in a significant number of patients with psoriasis and the relative absence of IgG- or IgM-containing CIC suggest that IgA-containing CIC may play a role in psoriasis. The lack of correlation with clinical improvement, however, suggests these IgA-containing CIC are not directly related to the cutaneous manifestations of psoriasis, but may be important in the modification of immune or inflammatory responses in these patients.

Duke Scholars

Published In

J Invest Dermatol

DOI

ISSN

0022-202X

Publication Date

June 1983

Volume

80

Issue

6

Start / End Page

465 / 468

Location

United States

Related Subject Headings

  • Ultracentrifugation
  • Radioimmunoassay
  • Psoriasis
  • Male
  • Iodine Radioisotopes
  • Immunoglobulin G
  • Immunoglobulin A
  • Humans
  • Female
  • Etretinate
 

Citation

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Hall, R. P., Peck, G. L., & Lawley, T. J. (1983). Circulating IgA immune complexes in patients with psoriasis. J Invest Dermatol, 80(6), 465–468. https://doi.org/10.1111/1523-1747.ep12534883
Hall, R. P., G. L. Peck, and T. J. Lawley. “Circulating IgA immune complexes in patients with psoriasis.J Invest Dermatol 80, no. 6 (June 1983): 465–68. https://doi.org/10.1111/1523-1747.ep12534883.
Hall RP, Peck GL, Lawley TJ. Circulating IgA immune complexes in patients with psoriasis. J Invest Dermatol. 1983 Jun;80(6):465–8.
Hall, R. P., et al. “Circulating IgA immune complexes in patients with psoriasis.J Invest Dermatol, vol. 80, no. 6, June 1983, pp. 465–68. Pubmed, doi:10.1111/1523-1747.ep12534883.
Hall RP, Peck GL, Lawley TJ. Circulating IgA immune complexes in patients with psoriasis. J Invest Dermatol. 1983 Jun;80(6):465–468.
Journal cover image

Published In

J Invest Dermatol

DOI

ISSN

0022-202X

Publication Date

June 1983

Volume

80

Issue

6

Start / End Page

465 / 468

Location

United States

Related Subject Headings

  • Ultracentrifugation
  • Radioimmunoassay
  • Psoriasis
  • Male
  • Iodine Radioisotopes
  • Immunoglobulin G
  • Immunoglobulin A
  • Humans
  • Female
  • Etretinate