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Seven-transmembrane receptors.

Publication ,  Journal Article
Pierce, KL; Premont, RT; Lefkowitz, RJ
Published in: Nat Rev Mol Cell Biol
September 2002
Published version (DOI) Link to item

Seven-transmembrane receptors, which constitute the largest, most ubiquitous and most versatile family of membrane receptors, are also the most common target of therapeutic drugs. Recent findings indicate that the classical models of G-protein coupling and activation of second-messenger-generating enzymes do not fully explain their remarkably diverse biological actions.

Duke Scholars

Robert J. Lefkowitz
Author Robert J. Lefkowitz Medicine, Cardiology
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Published In

Nat Rev Mol Cell Biol

DOI

10.1038/nrm908

ISSN

1471-0072

Publication Date

September 2002

Volume

3

Issue

9

Start / End Page

639 / 650

Location

England

Related Subject Headings

  • Yeasts
  • Signal Transduction
  • Receptors, Cell Surface
  • Humans
  • Heterotrimeric GTP-Binding Proteins
  • Down-Regulation
  • Dimerization
  • Developmental Biology
  • Cell Membrane
  • Animals
 

Citation

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Pierce, K. L., Premont, R. T., & Lefkowitz, R. J. (2002). Seven-transmembrane receptors. Nat Rev Mol Cell Biol, 3(9), 639–650. https://doi.org/10.1038/nrm908
Pierce, Kristen L., Richard T. Premont, and Robert J. Lefkowitz. “Seven-transmembrane receptors.” Nat Rev Mol Cell Biol 3, no. 9 (September 2002): 639–50. https://doi.org/10.1038/nrm908.
Pierce KL, Premont RT, Lefkowitz RJ. Seven-transmembrane receptors. Nat Rev Mol Cell Biol. 2002 Sep;3(9):639–50.
Pierce, Kristen L., et al. “Seven-transmembrane receptors.” Nat Rev Mol Cell Biol, vol. 3, no. 9, Sept. 2002, pp. 639–50. Pubmed, doi:10.1038/nrm908.
Pierce KL, Premont RT, Lefkowitz RJ. Seven-transmembrane receptors. Nat Rev Mol Cell Biol. 2002 Sep;3(9):639–650.

Published In

Nat Rev Mol Cell Biol

DOI

10.1038/nrm908

ISSN

1471-0072

Publication Date

September 2002

Volume

3

Issue

9

Start / End Page

639 / 650

Location

England

Related Subject Headings

  • Yeasts
  • Signal Transduction
  • Receptors, Cell Surface
  • Humans
  • Heterotrimeric GTP-Binding Proteins
  • Down-Regulation
  • Dimerization
  • Developmental Biology
  • Cell Membrane
  • Animals