'Resonant' solute uptake predicted by a model of endothelial permeability dynamics

Generally, the transport of macromolecules across the arterial endothelium, and their subsequent accumulation in the arterial wall is an important factor in the pathogenesis of atherosclerotic disease. It is hypothesized that endothelial permeability rises in relation to the rate at which the endothelial characteristics are changing. The implications of this hypothesis are explored using an a priori mathematical model of endothelial permeability dynamics developed for this purpose. In particular, the model is used to examine the dependence of long-term uptake of plasma macromolecules on the time scale of the hemodynamic fluctuations and the time constants of the endothelial response.

Duke Scholars

Author Morton Friedman Biomedical Engineering