Scholars@Duke

Miniature biochip system for bioenvironmental applications

Publication ,  Journal Article
Wabuyele, MB; Yan, F; Martin, ME; Griffin, GD; Stokes, DL; Stratis-Cullum, DN; Mobley, J; Vass, AA; Vo-Dinh, T
Published in: Proceedings of SPIE - The International Society for Optical Engineering
December 1, 2004
Published version (DOI)

An integrated multi-functional biochip based on integrated circuit complementary metal oxide semiconductor (CMOS) sensor array for use in medical diagnostics and pathogen detection has been described. The usefulness and potential of the biochip as a rapid, inexpensive screening tool for detection of bioenvironmental pathogens will be demonstrated. Detection of aerosolized spores was achieved by coupling the miniature system to a portable bioaerosol sampler, and the performance of the antibody-based recognition and enzyme amplification method was evaluated. The bioassay performance was found to be compatible with the air sampling device, and the enzymatic amplification was found to be an attractive amplification method for detection of low spore concentrations. The combined portable bioaerosol sampler and miniature biochip system detected 100 B. globigii spores, corresponding to 17 aerosolized spores/L of air.

Duke Scholars

Tuan Vo-Dinh
Author Tuan Vo-Dinh Biomedical Engineering

Published In

Proceedings of SPIE - The International Society for Optical Engineering

DOI

10.1117/12.580126

ISSN

0277-786X

Publication Date

December 1, 2004

Volume

5586

Start / End Page

26 / 32

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering
 

Citation

APA
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ICMJE
MLA
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Wabuyele, M. B., Yan, F., Martin, M. E., Griffin, G. D., Stokes, D. L., Stratis-Cullum, D. N., … Vo-Dinh, T. (2004). Miniature biochip system for bioenvironmental applications. Proceedings of SPIE - The International Society for Optical Engineering, 5586, 26–32. https://doi.org/10.1117/12.580126
Wabuyele, M. B., F. Yan, M. E. Martin, G. D. Griffin, D. L. Stokes, D. N. Stratis-Cullum, J. Mobley, A. A. Vass, and T. Vo-Dinh. “Miniature biochip system for bioenvironmental applications.” Proceedings of SPIE - The International Society for Optical Engineering 5586 (December 1, 2004): 26–32. https://doi.org/10.1117/12.580126.
Wabuyele MB, Yan F, Martin ME, Griffin GD, Stokes DL, Stratis-Cullum DN, et al. Miniature biochip system for bioenvironmental applications. Proceedings of SPIE - The International Society for Optical Engineering. 2004 Dec 1;5586:26–32.
Wabuyele, M. B., et al. “Miniature biochip system for bioenvironmental applications.” Proceedings of SPIE - The International Society for Optical Engineering, vol. 5586, Dec. 2004, pp. 26–32. Scopus, doi:10.1117/12.580126.
Wabuyele MB, Yan F, Martin ME, Griffin GD, Stokes DL, Stratis-Cullum DN, Mobley J, Vass AA, Vo-Dinh T. Miniature biochip system for bioenvironmental applications. Proceedings of SPIE - The International Society for Optical Engineering. 2004 Dec 1;5586:26–32.

Published In

Proceedings of SPIE - The International Society for Optical Engineering

DOI

10.1117/12.580126

ISSN

0277-786X

Publication Date

December 1, 2004

Volume

5586

Start / End Page

26 / 32

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering