One-dimensional model of cardiac defibrillation.

The response of a single strand of cardiac cells to a uniform defibrillatory shock assuming steady-state linear conditions is examined. It is argued that the effect of this current is quantitatively described by the induced transmembrane potential even under passive conditions. The characteristics of the single strand are those that would exist if the heart was a system of equivalent parallel pathways from apex to base. It is shown that essentially every cell is both hyperpolarized and depolarised from the shock by an amount proportional to the stimulus intensity and the intercellular junctional resistance. For physiological values of model parameters the evaluated depolarisations are consistent with levels necessary to affect electrophysiological behaviour.

Duke Scholars

Author Roger C. Barr Biomedical Engineering