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Contemporary approaches to prenatal diagnosis.

Publication ,  Journal Article
Kuller, JA; Laifer, SA
Published in: Am Fam Physician
December 1995

A variety of options for prenatal diagnosis are available to the pregnant woman. Maternal serum analyte analysis, performed between 15 and 20 weeks' gestation, provides a screening test for fetal neural tube defects and aneuploidy in low-risk pregnancies. Fetal ultrasound examination is of benefit in high-risk pregnancies. The necessity of prenatal screening in the low-risk patient with an established date of last menstrual period is more controversial. Ultrasound examination can establish gestational age, assess fetal number and position, determine placental location and amniotic fluid volume, and rule out major structural anomalies. Invasive fetal testing, including amniocentesis and chorionic villus sampling, should be offered to women who are 35 years of age or older or who have had abnormal results on noninvasive prenatal screening and in cases in which the parents are carriers of genetic conditions that are amenable to prenatal diagnosis.

Duke Scholars

Published In

Am Fam Physician

ISSN

0002-838X

Publication Date

December 1995

Volume

52

Issue

8

Start / End Page

2277 / 2286

Location

United States

Related Subject Headings

  • alpha-Fetoproteins
  • Ultrasonography, Prenatal
  • Prenatal Diagnosis
  • Pregnancy
  • Humans
  • General & Internal Medicine
  • Female
  • Estriol
  • Chorionic Villi Sampling
  • Chorionic Gonadotropin
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kuller, J. A., & Laifer, S. A. (1995). Contemporary approaches to prenatal diagnosis. Am Fam Physician, 52(8), 2277–2286.
Kuller, J. A., and S. A. Laifer. “Contemporary approaches to prenatal diagnosis.Am Fam Physician 52, no. 8 (December 1995): 2277–86.
Kuller JA, Laifer SA. Contemporary approaches to prenatal diagnosis. Am Fam Physician. 1995 Dec;52(8):2277–86.
Kuller, J. A., and S. A. Laifer. “Contemporary approaches to prenatal diagnosis.Am Fam Physician, vol. 52, no. 8, Dec. 1995, pp. 2277–86.
Kuller JA, Laifer SA. Contemporary approaches to prenatal diagnosis. Am Fam Physician. 1995 Dec;52(8):2277–2286.
Journal cover image

Published In

Am Fam Physician

ISSN

0002-838X

Publication Date

December 1995

Volume

52

Issue

8

Start / End Page

2277 / 2286

Location

United States

Related Subject Headings

  • alpha-Fetoproteins
  • Ultrasonography, Prenatal
  • Prenatal Diagnosis
  • Pregnancy
  • Humans
  • General & Internal Medicine
  • Female
  • Estriol
  • Chorionic Villi Sampling
  • Chorionic Gonadotropin