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Enforcing order within a complex locus: current perspectives on the control of V(D)J recombination at the murine T-cell receptor alpha/delta locus.

Publication ,  Journal Article
Krangel, MS; Carabana, J; Abbarategui, I; Schlimgen, R; Hawwari, A
Published in: Immunol Rev
August 2004

V(D)J recombination proceeds according to defined developmental programs at T-cell receptor (TCR) and immunoglobulin loci as a function of cell lineage and stage of differentiation. Although the molecular details are still lacking, such regulation is thought to occur at the level of accessibility of chromosomal recombination signal sequences to the recombinase. The unique and complex organization of the TCRalpha/delta locus poses intriguing regulatory challenges in this regard: embedded TCRalpha and TCRdelta gene segments rearrange at distinct stages of thymocyte development, there is a highly regulated progression of primary followed by secondary rearrangements involving Jalpha segments, and there are important developmental constraints on V gene segment usage. The locus therefore provides a fascinating laboratory in which to explore the basic mechanisms underlying developmental control. We provide here a current view of cis-acting mechanisms that enforce the TCRalpha/delta locus developmental program, and we emphasize the unresolved issues that command the attention of our and other laboratories.

Duke Scholars

Published In

Immunol Rev

DOI

ISSN

0105-2896

Publication Date

August 2004

Volume

200

Start / End Page

224 / 232

Location

England

Related Subject Headings

  • VDJ Recombinases
  • Recombination, Genetic
  • Receptors, Antigen, T-Cell, gamma-delta
  • Receptors, Antigen, T-Cell, alpha-beta
  • Mice
  • Immunology
  • Gene Rearrangement, delta-Chain T-Cell Antigen Receptor
  • Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor
  • Animals
  • 1107 Immunology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Krangel, M. S., Carabana, J., Abbarategui, I., Schlimgen, R., & Hawwari, A. (2004). Enforcing order within a complex locus: current perspectives on the control of V(D)J recombination at the murine T-cell receptor alpha/delta locus. Immunol Rev, 200, 224–232. https://doi.org/10.1111/j.0105-2896.2004.00155.x
Krangel, Michael S., Juan Carabana, Iratxe Abbarategui, Ryan Schlimgen, and Abbas Hawwari. “Enforcing order within a complex locus: current perspectives on the control of V(D)J recombination at the murine T-cell receptor alpha/delta locus.Immunol Rev 200 (August 2004): 224–32. https://doi.org/10.1111/j.0105-2896.2004.00155.x.
Krangel MS, Carabana J, Abbarategui I, Schlimgen R, Hawwari A. Enforcing order within a complex locus: current perspectives on the control of V(D)J recombination at the murine T-cell receptor alpha/delta locus. Immunol Rev. 2004 Aug;200:224–32.
Krangel, Michael S., et al. “Enforcing order within a complex locus: current perspectives on the control of V(D)J recombination at the murine T-cell receptor alpha/delta locus.Immunol Rev, vol. 200, Aug. 2004, pp. 224–32. Pubmed, doi:10.1111/j.0105-2896.2004.00155.x.
Krangel MS, Carabana J, Abbarategui I, Schlimgen R, Hawwari A. Enforcing order within a complex locus: current perspectives on the control of V(D)J recombination at the murine T-cell receptor alpha/delta locus. Immunol Rev. 2004 Aug;200:224–232.

Published In

Immunol Rev

DOI

ISSN

0105-2896

Publication Date

August 2004

Volume

200

Start / End Page

224 / 232

Location

England

Related Subject Headings

  • VDJ Recombinases
  • Recombination, Genetic
  • Receptors, Antigen, T-Cell, gamma-delta
  • Receptors, Antigen, T-Cell, alpha-beta
  • Mice
  • Immunology
  • Gene Rearrangement, delta-Chain T-Cell Antigen Receptor
  • Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor
  • Animals
  • 1107 Immunology