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Turning T-cell receptor beta recombination on and off: more questions than answers.

Publication ,  Journal Article
Jackson, AM; Krangel, MS
Published in: Immunol Rev
February 2006

Successful V(D)J recombination at the T-cell receptor beta (Tcrb) locus is critical for early thymocyte development. The locus is subject to a host of regulatory mechanisms that impart a strict developmental order to Tcrb recombination events and that insure that Tcrb recombination occurs in an allelically excluded fashion. Progress has been made in the understanding of the cis-acting control of Tcrb locus chromatin structure and the extent to which such accessibility control can account for the developmental regulation of Tcrb recombination. However, recent studies in our laboratory and elsewhere have made it abundantly clear that accessibility control is only part of the story, and multiple additional mechanisms impact both the developmental activation and inactivation of locus recombination events. Here we evaluate our current understanding of developmental regulation at the Tcrb locus. We highlight the many unresolved issues and we discuss how recent concepts emerging from studies of other antigen receptor loci may (or may not) help to resolve these issues.

Duke Scholars

Published In

Immunol Rev

DOI

ISSN

0105-2896

Publication Date

February 2006

Volume

209

Start / End Page

129 / 141

Location

England

Related Subject Headings

  • VDJ Recombinases
  • Thymus Gland
  • T-Lymphocytes
  • Receptors, Antigen, T-Cell, alpha-beta
  • Lymphopoiesis
  • Immunology
  • Humans
  • Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
  • Gene Expression Regulation, Developmental
  • Feedback, Physiological
 

Citation

APA
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ICMJE
MLA
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Jackson, A. M., & Krangel, M. S. (2006). Turning T-cell receptor beta recombination on and off: more questions than answers. Immunol Rev, 209, 129–141. https://doi.org/10.1111/j.0105-2896.2006.00342.x
Jackson, Annette M., and Michael S. Krangel. “Turning T-cell receptor beta recombination on and off: more questions than answers.Immunol Rev 209 (February 2006): 129–41. https://doi.org/10.1111/j.0105-2896.2006.00342.x.
Jackson AM, Krangel MS. Turning T-cell receptor beta recombination on and off: more questions than answers. Immunol Rev. 2006 Feb;209:129–41.
Jackson, Annette M., and Michael S. Krangel. “Turning T-cell receptor beta recombination on and off: more questions than answers.Immunol Rev, vol. 209, Feb. 2006, pp. 129–41. Pubmed, doi:10.1111/j.0105-2896.2006.00342.x.
Jackson AM, Krangel MS. Turning T-cell receptor beta recombination on and off: more questions than answers. Immunol Rev. 2006 Feb;209:129–141.

Published In

Immunol Rev

DOI

ISSN

0105-2896

Publication Date

February 2006

Volume

209

Start / End Page

129 / 141

Location

England

Related Subject Headings

  • VDJ Recombinases
  • Thymus Gland
  • T-Lymphocytes
  • Receptors, Antigen, T-Cell, alpha-beta
  • Lymphopoiesis
  • Immunology
  • Humans
  • Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
  • Gene Expression Regulation, Developmental
  • Feedback, Physiological