Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Vaginal adenosis in women born prior to the diethylstilbestrol era.

Publication ,  Journal Article
Robboy, SJ; Hill, EC; Sandberg, EC; Czernobilsky, B
Published in: Hum Pathol
May 1986

Vaginal adenosis was evaluated in 41 women, all of whom had been born prior to the diethylstilbestrol (DES) era, and compared with the adenosis commonly encountered in DES-exposed progeny. The patients were 24 to 88 years of age (median, 44 years). Six of the women were symptomatic, and in four of these six the glands were enmeshed in a marked inflammatory infiltrate. In an additional 26 women the adenosis was discovered as incidental, nonsymptomatic macroscopic nodules or cysts. The remaining nine cases of adenosis were discovered by pathologists. Three types of epithelia characterized the glands: mucinous, tuboendometrial, and embryonic. Mucinous columnar cells resembling the lining of the normal endocervix and tuboendometrial cells resembling the lining of the normal fallopian tube or endometrium constituted the glands exclusively in 22 and eight specimens, respectively, and as a mixture in seven. The glands lined by mucinous cells most often presented clinically as cysts or nodules. The specimens composed of tuboendometrial cells were most often discovered on microscopic examination. The third type of epithelium, composed of embryonic columnar cells, was encountered in four specimens. These glands, less than 30 micron in greatest diameter, were located at the junction between the lamina propria and the squamous epithelium, and were incidental microscopic findings. It is concluded that the microscopic appearances of adenosis in women born prior to the DES era are identical to those encountered in young women exposed in utero to DES.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Hum Pathol

DOI

ISSN

0046-8177

Publication Date

May 1986

Volume

17

Issue

5

Start / End Page

488 / 492

Location

United States

Related Subject Headings

  • Vagina
  • Uterus
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Pathology
  • Middle Aged
  • Humans
  • Genital Neoplasms, Female
  • Female
  • Fallopian Tubes
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Robboy, S. J., Hill, E. C., Sandberg, E. C., & Czernobilsky, B. (1986). Vaginal adenosis in women born prior to the diethylstilbestrol era. Hum Pathol, 17(5), 488–492. https://doi.org/10.1016/s0046-8177(86)80039-9
Robboy, S. J., E. C. Hill, E. C. Sandberg, and B. Czernobilsky. “Vaginal adenosis in women born prior to the diethylstilbestrol era.Hum Pathol 17, no. 5 (May 1986): 488–92. https://doi.org/10.1016/s0046-8177(86)80039-9.
Robboy SJ, Hill EC, Sandberg EC, Czernobilsky B. Vaginal adenosis in women born prior to the diethylstilbestrol era. Hum Pathol. 1986 May;17(5):488–92.
Robboy, S. J., et al. “Vaginal adenosis in women born prior to the diethylstilbestrol era.Hum Pathol, vol. 17, no. 5, May 1986, pp. 488–92. Pubmed, doi:10.1016/s0046-8177(86)80039-9.
Robboy SJ, Hill EC, Sandberg EC, Czernobilsky B. Vaginal adenosis in women born prior to the diethylstilbestrol era. Hum Pathol. 1986 May;17(5):488–492.
Journal cover image

Published In

Hum Pathol

DOI

ISSN

0046-8177

Publication Date

May 1986

Volume

17

Issue

5

Start / End Page

488 / 492

Location

United States

Related Subject Headings

  • Vagina
  • Uterus
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Pathology
  • Middle Aged
  • Humans
  • Genital Neoplasms, Female
  • Female
  • Fallopian Tubes