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Squamous cell dysplasia and carcinoma in situ of the cervix and vagina after prenatal exposure to diethylstilbestrol.

Publication ,  Journal Article
Robboy, SJ; Keh, PC; Nickerson, RJ; Helmanis, EK; Prat, J; Szyfelbein, WM; Taft, PD; Barnes, AB; Scully, RE; Welch, WR
Published in: Obstet Gynecol
May 1978

Squamous cell abnormalities of the vagina and cervix were evaluated in 1424 women exposed to diethylstilbestrol (DES) in utero. The prevalence of dysplasia was 2.1% and the incidence 0.85/100 person-years of followup. The dysplastic epithelial changes were almost always mild in women with no prior history of dysplasia and was slightly more frequent in the cervix than the vagina. Severe dysplasia and carcinoma in situ (CIS) were encountered only in those subjects specifically referred because of those abnormalities. The most common problem in the diagnosis of these squamous cell changes was the misinterpretation of mature and immature metaplastic cells for dysplastic squamous cells. Discordance between biopsy and cytology was common-place in the detection and followup of dysplasia, especially when it was mild. There were no instances in the study where cytology and biopsy samples from the vagina were both abnormal concurrently. Colposcopically directed biopsies did not increase the frequency of confirmation of cytologic findings. These data suggest that both cytology and biopsy of abnormal segments of the vagina and cervix remain an integral part of the examination of the DES-exposed female during long-term follow-up studies.

Duke Scholars

Published In

Obstet Gynecol

DOI

ISSN

0029-7844

Publication Date

May 1978

Volume

51

Issue

5

Start / End Page

528 / 535

Location

United States

Related Subject Headings

  • Vaginal Smears
  • Vaginal Neoplasms
  • Uterine Cervical Neoplasms
  • Uterine Cervical Dysplasia
  • Time Factors
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Humans
  • Fetus
  • Female
 

Citation

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NLM
Robboy, S. J., Keh, P. C., Nickerson, R. J., Helmanis, E. K., Prat, J., Szyfelbein, W. M., … Welch, W. R. (1978). Squamous cell dysplasia and carcinoma in situ of the cervix and vagina after prenatal exposure to diethylstilbestrol. Obstet Gynecol, 51(5), 528–535. https://doi.org/10.1097/00006250-197805000-00003
Robboy, S. J., P. C. Keh, R. J. Nickerson, E. K. Helmanis, J. Prat, W. M. Szyfelbein, P. D. Taft, A. B. Barnes, R. E. Scully, and W. R. Welch. “Squamous cell dysplasia and carcinoma in situ of the cervix and vagina after prenatal exposure to diethylstilbestrol.Obstet Gynecol 51, no. 5 (May 1978): 528–35. https://doi.org/10.1097/00006250-197805000-00003.
Robboy SJ, Keh PC, Nickerson RJ, Helmanis EK, Prat J, Szyfelbein WM, et al. Squamous cell dysplasia and carcinoma in situ of the cervix and vagina after prenatal exposure to diethylstilbestrol. Obstet Gynecol. 1978 May;51(5):528–35.
Robboy, S. J., et al. “Squamous cell dysplasia and carcinoma in situ of the cervix and vagina after prenatal exposure to diethylstilbestrol.Obstet Gynecol, vol. 51, no. 5, May 1978, pp. 528–35. Pubmed, doi:10.1097/00006250-197805000-00003.
Robboy SJ, Keh PC, Nickerson RJ, Helmanis EK, Prat J, Szyfelbein WM, Taft PD, Barnes AB, Scully RE, Welch WR. Squamous cell dysplasia and carcinoma in situ of the cervix and vagina after prenatal exposure to diethylstilbestrol. Obstet Gynecol. 1978 May;51(5):528–535.
Journal cover image

Published In

Obstet Gynecol

DOI

ISSN

0029-7844

Publication Date

May 1978

Volume

51

Issue

5

Start / End Page

528 / 535

Location

United States

Related Subject Headings

  • Vaginal Smears
  • Vaginal Neoplasms
  • Uterine Cervical Neoplasms
  • Uterine Cervical Dysplasia
  • Time Factors
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Humans
  • Fetus
  • Female