Skip to main content
Journal cover image

Glycemic monitoring in diabetics with sickle cell plus beta-thalassemia hemoglobinopathy.

Publication ,  Journal Article
Kosecki, SM; Rodgers, PT; Adams, MB
Published in: Ann Pharmacother
September 2005

OBJECTIVE: To report a case of diabetes management in a patient with a hemoglobinopathy that caused her clinician to seek a different measure of glycemic control, fructosamine, rather than glycosylated hemoglobin (HbA1c). CASE SUMMARY: A 53-year-old African American woman presented with a past medical history of type 2 diabetes, hypertension, seizure disorder, rheumatoid arthritis, and sickle cell disease plus beta-thalassemia. She reported fasting blood glucose values ranging broadly from 50 to 320 mg/dL, yet her HbA1c result remained steady in a low range of <6%. A measure of fructosamine returned elevated at 340 micromol/L (reference range 200-300). DISCUSSION: We believe that this patient's hemoglobinopathy resulted in falsely low levels of HbA1c, and we substantiate this interpretation with the patient's self-monitored blood glucose values from home that appeared higher and inconsistent with the HbA1c results. Although few reports on using the measure of fructosamine appear in the literature, this patient's high fructosamine result supports fructosamine as the more appropriate measure of glycemic control. CONCLUSIONS: Serum fructosamine levels may be considered as an appropriate laboratory measurement when monitoring long-term glycemic control in patients with type 2 diabetes mellitus and sickle cell disease.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Ann Pharmacother

DOI

ISSN

1060-0280

Publication Date

September 2005

Volume

39

Issue

9

Start / End Page

1557 / 1560

Location

United States

Related Subject Headings

  • beta-Thalassemia
  • Pharmacology & Pharmacy
  • Middle Aged
  • Humans
  • Glycated Hemoglobin
  • Fructosamine
  • Female
  • Diabetes Mellitus, Type 2
  • Blood Glucose Self-Monitoring
  • Blood Glucose
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kosecki, S. M., Rodgers, P. T., & Adams, M. B. (2005). Glycemic monitoring in diabetics with sickle cell plus beta-thalassemia hemoglobinopathy. Ann Pharmacother, 39(9), 1557–1560. https://doi.org/10.1345/aph.1G010
Kosecki, Sheri M., Philip T. Rodgers, and Martha B. Adams. “Glycemic monitoring in diabetics with sickle cell plus beta-thalassemia hemoglobinopathy.Ann Pharmacother 39, no. 9 (September 2005): 1557–60. https://doi.org/10.1345/aph.1G010.
Kosecki SM, Rodgers PT, Adams MB. Glycemic monitoring in diabetics with sickle cell plus beta-thalassemia hemoglobinopathy. Ann Pharmacother. 2005 Sep;39(9):1557–60.
Kosecki, Sheri M., et al. “Glycemic monitoring in diabetics with sickle cell plus beta-thalassemia hemoglobinopathy.Ann Pharmacother, vol. 39, no. 9, Sept. 2005, pp. 1557–60. Pubmed, doi:10.1345/aph.1G010.
Kosecki SM, Rodgers PT, Adams MB. Glycemic monitoring in diabetics with sickle cell plus beta-thalassemia hemoglobinopathy. Ann Pharmacother. 2005 Sep;39(9):1557–1560.
Journal cover image

Published In

Ann Pharmacother

DOI

ISSN

1060-0280

Publication Date

September 2005

Volume

39

Issue

9

Start / End Page

1557 / 1560

Location

United States

Related Subject Headings

  • beta-Thalassemia
  • Pharmacology & Pharmacy
  • Middle Aged
  • Humans
  • Glycated Hemoglobin
  • Fructosamine
  • Female
  • Diabetes Mellitus, Type 2
  • Blood Glucose Self-Monitoring
  • Blood Glucose