Skip to main content

Sympatho-adrenal development in perinatally addicted rats.

Publication ,  Journal Article
Slotkin, TA; Anderson, TR
Published in: Addict Dis
1975

Chronic morphine administration in adult rats results in neurogenic secretion of adrenal catecholamines and compensatory increases in basal catecholamine levels, in activities of catecholamine biosynthetic enzymes and in the number of storage vesicles in the tissue. Perinatally addicted developing rats demonstrated changes completely different from those seen in adults; catecholamine levels and dopamine beta-hydroxylase activity were reduced compared to controlscsnnofinduction of tyrosine hydroxylase was observed. The time course of adrenomedullary maturation was delayed throuth the first 10-20 days of age, with reduced numbers of storage vesicles and larger proportions of partially filled vesicles. On exposure to morphine, continued until weaning, perinatally addicted rats did not display any of the changes in catecholamine synthesis or uptake seen in adult rats. The differences between adults and developing rats can be partly explained by the absence of functional innervation of the neonatal adrenal medulla.

Duke Scholars

Published In

Addict Dis

ISSN

0094-0267

Publication Date

1975

Volume

2

Issue

1-2

Start / End Page

293 / 306

Location

United States

Related Subject Headings

  • Tyrosine 3-Monooxygenase
  • Substance-Related Disorders
  • Stimulation, Chemical
  • Splanchnic Nerves
  • Rats
  • Pregnancy
  • Morphine
  • Metaraminol
  • Maternal-Fetal Exchange
  • Insulin
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Slotkin, T. A., & Anderson, T. R. (1975). Sympatho-adrenal development in perinatally addicted rats. Addict Dis, 2(1–2), 293–306.
Slotkin, T. A., and T. R. Anderson. “Sympatho-adrenal development in perinatally addicted rats.Addict Dis 2, no. 1–2 (1975): 293–306.
Slotkin TA, Anderson TR. Sympatho-adrenal development in perinatally addicted rats. Addict Dis. 1975;2(1–2):293–306.
Slotkin, T. A., and T. R. Anderson. “Sympatho-adrenal development in perinatally addicted rats.Addict Dis, vol. 2, no. 1–2, 1975, pp. 293–306.
Slotkin TA, Anderson TR. Sympatho-adrenal development in perinatally addicted rats. Addict Dis. 1975;2(1–2):293–306.

Published In

Addict Dis

ISSN

0094-0267

Publication Date

1975

Volume

2

Issue

1-2

Start / End Page

293 / 306

Location

United States

Related Subject Headings

  • Tyrosine 3-Monooxygenase
  • Substance-Related Disorders
  • Stimulation, Chemical
  • Splanchnic Nerves
  • Rats
  • Pregnancy
  • Morphine
  • Metaraminol
  • Maternal-Fetal Exchange
  • Insulin