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Effects of reserpine on the adrenal medulla of the spontaneously hypertensive rat.

Publication ,  Journal Article
Slotkin, TA
Published in: Br J Pharmacol
March 1975

1. Reserpine administration resulted in a larger initial decline in adrenal catecholamines in spontaneously hypertensive rats (SHR) than in normotensive Wistar rats (NWR); the difference was eliminated by pretreatment with cholisdondamine. 2. Reserpine also produced a larger increase in SHR catecholamines and dopamine beta-hydroxylase several days later; chlorisondamine pretreatment did not prevent the increases, although it did slightly slow the increases. 3. Vesicles from SHR, or NWR incubated with reserpine in vitro demonstrated equivalent inhibition of adenosine 5'-triphosphate (ATP)-Mg-2+-stimulated adrenaline uptake. 4. Recovery of uptake was more rapid in SHR than in NWR after reserpine inhibition, and this was associated with a burst of new vesicle synthesis in the SHR; chlorisondamine pretreatment reduced the number of new, immature vesicles in reserpine-treated SHR. 5. Both SHR and NWR secreted equal proportions of their adrenal catecholamine contents after nicotine administration. 6. These data suggest that the sympatho-adrenal system of the SHR exhibits an enhanced reflex response to reserpine but that reserpine is equally effective in SHR and NWR in producing blockade of vesicular catecholamine transport; these alterations can affect markedly the actions of autonomic drugs in the SHR.

Duke Scholars

Published In

Br J Pharmacol

DOI

ISSN

0007-1188

Publication Date

March 1975

Volume

53

Issue

3

Start / End Page

349 / 356

Location

England

Related Subject Headings

  • Time Factors
  • Reserpine
  • Rats
  • Pharmacology & Pharmacy
  • Nicotine
  • In Vitro Techniques
  • Hypertension
  • Harmine
  • Female
  • Dopamine beta-Hydroxylase
 

Citation

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Slotkin, T. A. (1975). Effects of reserpine on the adrenal medulla of the spontaneously hypertensive rat. Br J Pharmacol, 53(3), 349–356. https://doi.org/10.1111/j.1476-5381.1975.tb07370.x
Slotkin, T. A. “Effects of reserpine on the adrenal medulla of the spontaneously hypertensive rat.Br J Pharmacol 53, no. 3 (March 1975): 349–56. https://doi.org/10.1111/j.1476-5381.1975.tb07370.x.
Slotkin, T. A. “Effects of reserpine on the adrenal medulla of the spontaneously hypertensive rat.Br J Pharmacol, vol. 53, no. 3, Mar. 1975, pp. 349–56. Pubmed, doi:10.1111/j.1476-5381.1975.tb07370.x.
Journal cover image

Published In

Br J Pharmacol

DOI

ISSN

0007-1188

Publication Date

March 1975

Volume

53

Issue

3

Start / End Page

349 / 356

Location

England

Related Subject Headings

  • Time Factors
  • Reserpine
  • Rats
  • Pharmacology & Pharmacy
  • Nicotine
  • In Vitro Techniques
  • Hypertension
  • Harmine
  • Female
  • Dopamine beta-Hydroxylase