Effects of alpha-fluoromethylhistidine (FMH), an irreversible inhibitor of histidine decarboxylase, on development of brain histamine and catecholamine systems in the neonatal rat.
Publication
, Journal Article
Slotkin, TA; Slepetis, RJ; Weigel, SJ; Whitmore, WL
Published in: Life Sci
June 20, 1983
Daily administration of FMH to neonatal rats produced long-lasting inhibition of histidine decarboxylase in hypothalamus and cerebral cortex and led to depletion of histamine in both brain regions. The onset of depletion was more rapid in cerebral cortex, a region in which non-neurotransmitter pools of histamine predominate in early postnatal life, appearing as early as postnatal day 3; depletion in the hypothalamus, a region rich in histaminergic neuronal projections, appeared later. No effects were seen on body or brain growth, nor was development of other biogenic amine systems affected. FMH thus provides a selective probe for examining the role of histamine in brain development.
Duke Scholars
Published In
Life Sci
DOI
ISSN
0024-3205
Publication Date
June 20, 1983
Volume
32
Issue
25
Start / End Page
2897 / 2903
Location
Netherlands
Related Subject Headings
- Rats, Inbred Strains
- Rats
- Pharmacology & Pharmacy
- Norepinephrine
- Methylhistidines
- Hypothalamus
- Histidine Decarboxylase
- Histidine
- Histamine
- Dopamine
Citation
APA
Chicago
ICMJE
MLA
NLM
Slotkin, T. A., Slepetis, R. J., Weigel, S. J., & Whitmore, W. L. (1983). Effects of alpha-fluoromethylhistidine (FMH), an irreversible inhibitor of histidine decarboxylase, on development of brain histamine and catecholamine systems in the neonatal rat. Life Sci, 32(25), 2897–2903. https://doi.org/10.1016/0024-3205(83)90326-0
Slotkin, T. A., R. J. Slepetis, S. J. Weigel, and W. L. Whitmore. “Effects of alpha-fluoromethylhistidine (FMH), an irreversible inhibitor of histidine decarboxylase, on development of brain histamine and catecholamine systems in the neonatal rat.” Life Sci 32, no. 25 (June 20, 1983): 2897–2903. https://doi.org/10.1016/0024-3205(83)90326-0.
Slotkin TA, Slepetis RJ, Weigel SJ, Whitmore WL. Effects of alpha-fluoromethylhistidine (FMH), an irreversible inhibitor of histidine decarboxylase, on development of brain histamine and catecholamine systems in the neonatal rat. Life Sci. 1983 Jun 20;32(25):2897–903.
Slotkin, T. A., et al. “Effects of alpha-fluoromethylhistidine (FMH), an irreversible inhibitor of histidine decarboxylase, on development of brain histamine and catecholamine systems in the neonatal rat.” Life Sci, vol. 32, no. 25, June 1983, pp. 2897–903. Pubmed, doi:10.1016/0024-3205(83)90326-0.
Slotkin TA, Slepetis RJ, Weigel SJ, Whitmore WL. Effects of alpha-fluoromethylhistidine (FMH), an irreversible inhibitor of histidine decarboxylase, on development of brain histamine and catecholamine systems in the neonatal rat. Life Sci. 1983 Jun 20;32(25):2897–2903.
Published In
Life Sci
DOI
ISSN
0024-3205
Publication Date
June 20, 1983
Volume
32
Issue
25
Start / End Page
2897 / 2903
Location
Netherlands
Related Subject Headings
- Rats, Inbred Strains
- Rats
- Pharmacology & Pharmacy
- Norepinephrine
- Methylhistidines
- Hypothalamus
- Histidine Decarboxylase
- Histidine
- Histamine
- Dopamine