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Effects of alpha-fluoromethylhistidine (FMH), an irreversible inhibitor of histidine decarboxylase, on development of brain histamine and catecholamine systems in the neonatal rat.

Publication ,  Journal Article
Slotkin, TA; Slepetis, RJ; Weigel, SJ; Whitmore, WL
Published in: Life Sci
June 20, 1983

Daily administration of FMH to neonatal rats produced long-lasting inhibition of histidine decarboxylase in hypothalamus and cerebral cortex and led to depletion of histamine in both brain regions. The onset of depletion was more rapid in cerebral cortex, a region in which non-neurotransmitter pools of histamine predominate in early postnatal life, appearing as early as postnatal day 3; depletion in the hypothalamus, a region rich in histaminergic neuronal projections, appeared later. No effects were seen on body or brain growth, nor was development of other biogenic amine systems affected. FMH thus provides a selective probe for examining the role of histamine in brain development.

Duke Scholars

Published In

Life Sci

DOI

ISSN

0024-3205

Publication Date

June 20, 1983

Volume

32

Issue

25

Start / End Page

2897 / 2903

Location

Netherlands

Related Subject Headings

  • Rats, Inbred Strains
  • Rats
  • Pharmacology & Pharmacy
  • Norepinephrine
  • Methylhistidines
  • Hypothalamus
  • Histidine Decarboxylase
  • Histidine
  • Histamine
  • Dopamine
 

Citation

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Slotkin, T. A., Slepetis, R. J., Weigel, S. J., & Whitmore, W. L. (1983). Effects of alpha-fluoromethylhistidine (FMH), an irreversible inhibitor of histidine decarboxylase, on development of brain histamine and catecholamine systems in the neonatal rat. Life Sci, 32(25), 2897–2903. https://doi.org/10.1016/0024-3205(83)90326-0
Slotkin, T. A., R. J. Slepetis, S. J. Weigel, and W. L. Whitmore. “Effects of alpha-fluoromethylhistidine (FMH), an irreversible inhibitor of histidine decarboxylase, on development of brain histamine and catecholamine systems in the neonatal rat.Life Sci 32, no. 25 (June 20, 1983): 2897–2903. https://doi.org/10.1016/0024-3205(83)90326-0.
Slotkin, T. A., et al. “Effects of alpha-fluoromethylhistidine (FMH), an irreversible inhibitor of histidine decarboxylase, on development of brain histamine and catecholamine systems in the neonatal rat.Life Sci, vol. 32, no. 25, June 1983, pp. 2897–903. Pubmed, doi:10.1016/0024-3205(83)90326-0.
Journal cover image

Published In

Life Sci

DOI

ISSN

0024-3205

Publication Date

June 20, 1983

Volume

32

Issue

25

Start / End Page

2897 / 2903

Location

Netherlands

Related Subject Headings

  • Rats, Inbred Strains
  • Rats
  • Pharmacology & Pharmacy
  • Norepinephrine
  • Methylhistidines
  • Hypothalamus
  • Histidine Decarboxylase
  • Histidine
  • Histamine
  • Dopamine