Role of ornithine decarboxylase in cardiac growth and hypertrophy.
Publication
, Journal Article
Bartolome, J; Huguenard, J; Slotkin, TA
Published in: Science
November 14, 1980
Inhibition of cardiac ornithine decarboxylase (ODC) by alpha-difluoromethylornithine (DFMO) did not prevent normal cardiac growth in mature rats but attenuated isoproterenol-induced hypertrophy. Hypertrophy caused by triiodothyronine was not prevented by DFMO. There appear to be both ODC-dependent and ODC-independent processes contributing to the subcellular mechanisms associated with growth, which must be considered in the potential laboratory and clinical use of DFMO.
Duke Scholars
Published In
Science
DOI
ISSN
0036-8075
Publication Date
November 14, 1980
Volume
210
Issue
4471
Start / End Page
793 / 794
Location
United States
Related Subject Headings
- Triiodothyronine
- Rats
- Ornithine Decarboxylase Inhibitors
- Ornithine Decarboxylase
- Ornithine
- Myocardium
- Male
- Isoproterenol
- Heart
- General Science & Technology
Citation
APA
Chicago
ICMJE
MLA
NLM
Bartolome, J., Huguenard, J., & Slotkin, T. A. (1980). Role of ornithine decarboxylase in cardiac growth and hypertrophy. Science, 210(4471), 793–794. https://doi.org/10.1126/science.6449079
Bartolome, J., J. Huguenard, and T. A. Slotkin. “Role of ornithine decarboxylase in cardiac growth and hypertrophy.” Science 210, no. 4471 (November 14, 1980): 793–94. https://doi.org/10.1126/science.6449079.
Bartolome J, Huguenard J, Slotkin TA. Role of ornithine decarboxylase in cardiac growth and hypertrophy. Science. 1980 Nov 14;210(4471):793–4.
Bartolome, J., et al. “Role of ornithine decarboxylase in cardiac growth and hypertrophy.” Science, vol. 210, no. 4471, Nov. 1980, pp. 793–94. Pubmed, doi:10.1126/science.6449079.
Bartolome J, Huguenard J, Slotkin TA. Role of ornithine decarboxylase in cardiac growth and hypertrophy. Science. 1980 Nov 14;210(4471):793–794.
Published In
Science
DOI
ISSN
0036-8075
Publication Date
November 14, 1980
Volume
210
Issue
4471
Start / End Page
793 / 794
Location
United States
Related Subject Headings
- Triiodothyronine
- Rats
- Ornithine Decarboxylase Inhibitors
- Ornithine Decarboxylase
- Ornithine
- Myocardium
- Male
- Isoproterenol
- Heart
- General Science & Technology