Central catecholaminergic lesions in the developing rat: effects of cardiac noradrenaline levels, turnover and release.

1. The role of the central nervous system in regulating cardiac sympathetic tone was examined in developing rats with neonatal central catecholaminergic lesions produced by intracisternal 6-hydroxydopamine treatment. 2. Lesioned animals showed a persistent deficit in both cardiac noradrenaline levels and spontaneous turnover rate as evaluated by alpha-methyl-p-tyrosine treatment. 3. Despite these deficits, tyramine was fully capable of releasing cardiac noradrenaline and short-term centrally-mediated release also could be elicited by exposure to cold or by swimming exercise. 4. The alterations in cardiac noradrenaline content produced by the central lesions may result from long-term reductions in sympathetic tone which do not necessarily compromise short-term response capabilities of the sympathetic system.

Duke Scholars

Author Theodore Alan Slotkin Pharmacology & Cancer Biology