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Effects of neonatal methylmercury exposure on adrenergic receptor binding sites in peripheral tissues of the developing rat.

Publication ,  Journal Article
Slotkin, TA; Kavlock, RJ; Cowdery, T; Orband, L; Bartolome, M; Whitmore, WL; Bartolome, J
Published in: Toxicology
October 1986

Neonatal exposure to methylmercury produces changes in patterns of tissue growth and function, in part, due to alterations in adrenergic neuronal input. To explore the mechanisms by which these changes come about, newborn rats were exposed to methylmercury (1 or 2.5 mg/kg per day) throughout the preweaning stage and the ontogeny of adrenergic receptor binding sites evaluated in liver, kidney, heart and lung, using [3H]prazosin (alpha 1-receptors), [3H]rauwolscine (alpha 2-receptors) and [125I]pindolol (beta-receptors). In the kidney, methylmercury caused decreases in beta- and alpha 1-receptor binding and increases in alpha 2-binding; previous work has shown that beta-receptor-mediated responses are generally enhanced in methylmercury-exposed pups, and the down-regulation of beta-receptor binding thus probably represents a compensatory action secondary to alterations in post-receptor coupling mechanisms. The effects of methylmercury on hepatic adrenergic receptors were different from those seen in the kidney, with substantial elevations in beta- and alpha 1-receptor binding apparent in the preweaning stage; this agrees also with the differences in effects of the mercurial on trophic reactivity and growth in the 2 tissues. Despite the fact that methylmercury causes activation of neonatal cardiac sympathetic nerves, beta-receptor binding sites in the heart were unaffected by methylmercury exposure; the failure to down-regulate cardiac postsynaptic receptors in the face of increased nerve activity again represents an anomaly of synaptic regulatory function. These results indicate that methylmercury alters adrenergic responsiveness, in part, through actions on the development of receptor binding sites, and further, that the organ-specificity and receptor subtype-selectivity are consistent with subsequent effects of the organomercurial on adrenergic participation in target organ growth; however, changes in receptor binding alone do not account for all of the effects of methylmercury on synaptic activity or trophic responses.

Duke Scholars

Published In

Toxicology

DOI

ISSN

0300-483X

Publication Date

October 1986

Volume

41

Issue

1

Start / End Page

95 / 106

Location

Ireland

Related Subject Headings

  • Yohimbine
  • Toxicology
  • Receptors, Adrenergic, alpha
  • Rats, Inbred Strains
  • Rats
  • Prazosin
  • Methylmercury Compounds
  • Male
  • Lung
  • Liver
 

Citation

APA
Chicago
ICMJE
MLA
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Slotkin, T. A., Kavlock, R. J., Cowdery, T., Orband, L., Bartolome, M., Whitmore, W. L., & Bartolome, J. (1986). Effects of neonatal methylmercury exposure on adrenergic receptor binding sites in peripheral tissues of the developing rat. Toxicology, 41(1), 95–106. https://doi.org/10.1016/0300-483x(86)90107-1
Slotkin, T. A., R. J. Kavlock, T. Cowdery, L. Orband, M. Bartolome, W. L. Whitmore, and J. Bartolome. “Effects of neonatal methylmercury exposure on adrenergic receptor binding sites in peripheral tissues of the developing rat.Toxicology 41, no. 1 (October 1986): 95–106. https://doi.org/10.1016/0300-483x(86)90107-1.
Slotkin TA, Kavlock RJ, Cowdery T, Orband L, Bartolome M, Whitmore WL, et al. Effects of neonatal methylmercury exposure on adrenergic receptor binding sites in peripheral tissues of the developing rat. Toxicology. 1986 Oct;41(1):95–106.
Slotkin, T. A., et al. “Effects of neonatal methylmercury exposure on adrenergic receptor binding sites in peripheral tissues of the developing rat.Toxicology, vol. 41, no. 1, Oct. 1986, pp. 95–106. Pubmed, doi:10.1016/0300-483x(86)90107-1.
Slotkin TA, Kavlock RJ, Cowdery T, Orband L, Bartolome M, Whitmore WL, Bartolome J. Effects of neonatal methylmercury exposure on adrenergic receptor binding sites in peripheral tissues of the developing rat. Toxicology. 1986 Oct;41(1):95–106.
Journal cover image

Published In

Toxicology

DOI

ISSN

0300-483X

Publication Date

October 1986

Volume

41

Issue

1

Start / End Page

95 / 106

Location

Ireland

Related Subject Headings

  • Yohimbine
  • Toxicology
  • Receptors, Adrenergic, alpha
  • Rats, Inbred Strains
  • Rats
  • Prazosin
  • Methylmercury Compounds
  • Male
  • Lung
  • Liver