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Organ specificity of neonatal methyl mercury hydroxide poisoning in the rat: effects of ornithine decarboxylase activity in developing tissues.

Publication ,  Journal Article
Bartolome, J; Chait, EA; Trepanier, P; Whitmore, WL; Weigel, S; Slotkin, TA
Published in: Toxicol Lett
October 1982

To determine the organ specificity of neonatal mercury hydroxide (CH3HgOH) exposure on biochemical development of its potential target tissues, effects on rat brain, liver, heart and kidney were compared utilizing the ontogenetic pattern of ornithine decarboxylase (ODC) activity, an early index of perturbation of cellular maturation. CH3HgOH was given daily beginning at birth for up to 21 days, using three dose levels (1, 2.5 or 5 mg/kg s.c.). In the brain, CH3HgOH treatment resulted in an initial reduction in ODC followed by a subsequent elevation of activity, a maturational pattern known to be associated with delayed cellular development. In contrast to the effects of CH3HgOH on brain, the pattern obtained in the liver, an initial elevation followed by a subsequent decline, is usually associated with compression of the time couse of cellular development. In the heart and kidney, CH3HgOH produced sustained elevations of ODC representing prolongation of the developmental period of rapid tissue growth and development; these patterns were associated with tissue hypertrophy which was sustained through the preweaning stage for both tissues and well into the postweaning period for the kidney. The results obtained with ODC clearly demonstrate that neonatal CH3HgOH poisoning causes organ-specific biochemical lesions which can play a role in subsequent effects on overall tissue development.

Duke Scholars

Published In

Toxicol Lett

DOI

ISSN

0378-4274

Publication Date

October 1982

Volume

13

Issue

3-4

Start / End Page

267 / 276

Location

Netherlands

Related Subject Headings

  • Toxicology
  • Rats, Inbred Strains
  • Rats
  • Pregnancy
  • Ornithine Decarboxylase
  • Organ Specificity
  • Organ Size
  • Methylmercury Compounds
  • Female
  • Carboxy-Lyases
 

Citation

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Bartolome, J., Chait, E. A., Trepanier, P., Whitmore, W. L., Weigel, S., & Slotkin, T. A. (1982). Organ specificity of neonatal methyl mercury hydroxide poisoning in the rat: effects of ornithine decarboxylase activity in developing tissues. Toxicol Lett, 13(3–4), 267–276. https://doi.org/10.1016/0378-4274(82)90222-3
Bartolome, J., E. A. Chait, P. Trepanier, W. L. Whitmore, S. Weigel, and T. A. Slotkin. “Organ specificity of neonatal methyl mercury hydroxide poisoning in the rat: effects of ornithine decarboxylase activity in developing tissues.Toxicol Lett 13, no. 3–4 (October 1982): 267–76. https://doi.org/10.1016/0378-4274(82)90222-3.
Bartolome J, Chait EA, Trepanier P, Whitmore WL, Weigel S, Slotkin TA. Organ specificity of neonatal methyl mercury hydroxide poisoning in the rat: effects of ornithine decarboxylase activity in developing tissues. Toxicol Lett. 1982 Oct;13(3–4):267–76.
Bartolome, J., et al. “Organ specificity of neonatal methyl mercury hydroxide poisoning in the rat: effects of ornithine decarboxylase activity in developing tissues.Toxicol Lett, vol. 13, no. 3–4, Oct. 1982, pp. 267–76. Pubmed, doi:10.1016/0378-4274(82)90222-3.
Bartolome J, Chait EA, Trepanier P, Whitmore WL, Weigel S, Slotkin TA. Organ specificity of neonatal methyl mercury hydroxide poisoning in the rat: effects of ornithine decarboxylase activity in developing tissues. Toxicol Lett. 1982 Oct;13(3–4):267–276.
Journal cover image

Published In

Toxicol Lett

DOI

ISSN

0378-4274

Publication Date

October 1982

Volume

13

Issue

3-4

Start / End Page

267 / 276

Location

Netherlands

Related Subject Headings

  • Toxicology
  • Rats, Inbred Strains
  • Rats
  • Pregnancy
  • Ornithine Decarboxylase
  • Organ Specificity
  • Organ Size
  • Methylmercury Compounds
  • Female
  • Carboxy-Lyases