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Altered localization of choline transporter sites in the mouse hippocampus after prenatal heroin exposure.

Publication ,  Journal Article
Vatury, O; Barg, J; Slotkin, TA; Yanai, J
Published in: Brain Res Bull
March 1, 2004

Prenatal heroin exposure disrupts hippocampal cholinergic synaptic function and related behaviors. Biochemical studies indicate an increase in the number of presynaptic high-affinity choline transporter (HACT) sites, as assessed by [3H]hemicholinium-3 (HC-3) binding. The present study was designed to assess whether this effect involves global upregulation of the transporter, or whether disruption occurs with a specific tempero-spatial distribution. Pregnant mice were given 10mg/kg per day of heroin subcutaneously on gestational days (GD) 9-18. Autoradiographic distribution of HC-3 binding sites was evaluated in the hippocampus of the offspring at postnatal days 15, 25, and 53. These results, suggestive of hippocampal "miswiring," are likely to explain the net impairment of cholinergic synaptic function after prenatal heroin exposure, despite the simultaneous upregulation of both presynaptic cholinergic activity and postsynaptic receptors. Understanding the subregional selectivity of hippocampal defects can lead to the development of strategies that may potentially enable therapeutic interventions to offset or reverse the neurobehavioral defects.

Duke Scholars

Published In

Brain Res Bull

DOI

ISSN

0361-9230

Publication Date

March 1, 2004

Volume

63

Issue

1

Start / End Page

25 / 32

Location

United States

Related Subject Headings

  • Synaptic Transmission
  • Synaptic Membranes
  • Radioligand Assay
  • Presynaptic Terminals
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Neurology & Neurosurgery
  • Neural Pathways
  • Mice
  • Membrane Transport Proteins
 

Citation

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ICMJE
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Vatury, O., Barg, J., Slotkin, T. A., & Yanai, J. (2004). Altered localization of choline transporter sites in the mouse hippocampus after prenatal heroin exposure. Brain Res Bull, 63(1), 25–32. https://doi.org/10.1016/j.brainresbull.2003.11.004
Vatury, Ori, Jacob Barg, Theodore A. Slotkin, and Joseph Yanai. “Altered localization of choline transporter sites in the mouse hippocampus after prenatal heroin exposure.Brain Res Bull 63, no. 1 (March 1, 2004): 25–32. https://doi.org/10.1016/j.brainresbull.2003.11.004.
Vatury O, Barg J, Slotkin TA, Yanai J. Altered localization of choline transporter sites in the mouse hippocampus after prenatal heroin exposure. Brain Res Bull. 2004 Mar 1;63(1):25–32.
Vatury, Ori, et al. “Altered localization of choline transporter sites in the mouse hippocampus after prenatal heroin exposure.Brain Res Bull, vol. 63, no. 1, Mar. 2004, pp. 25–32. Pubmed, doi:10.1016/j.brainresbull.2003.11.004.
Vatury O, Barg J, Slotkin TA, Yanai J. Altered localization of choline transporter sites in the mouse hippocampus after prenatal heroin exposure. Brain Res Bull. 2004 Mar 1;63(1):25–32.
Journal cover image

Published In

Brain Res Bull

DOI

ISSN

0361-9230

Publication Date

March 1, 2004

Volume

63

Issue

1

Start / End Page

25 / 32

Location

United States

Related Subject Headings

  • Synaptic Transmission
  • Synaptic Membranes
  • Radioligand Assay
  • Presynaptic Terminals
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Neurology & Neurosurgery
  • Neural Pathways
  • Mice
  • Membrane Transport Proteins