Skip to main content

Pulmonary gas exchange in humans exercising at sea level and simulated altitude.

Publication ,  Journal Article
Wagner, PD; Gale, GE; Moon, RE; Torre-Bueno, JR; Stolp, BW; Saltzman, HA
Published in: J Appl Physiol (1985)
July 1986

In a previous study of normal subjects exercising at sea level and simulated altitude, ventilation-perfusion (VA/Q) inequality and alveolar-end-capillary O2 diffusion limitation (DIFF) were found to increase on exercise at altitude, but at sea level the changes did not reach statistical significance. This paper reports additional measurements of VA/Q inequality and DIFF (at sea level and altitude) and also of pulmonary arterial pressure. This was to examine the hypothesis that VA/Q inequality is related to increased pulmonary arterial pressure. In a hypobaric chamber, eight normal subjects were exposed to barometric pressures of 752, 523, and 429 Torr (sea level, 10,000 ft, and 15,000 ft) in random order. At each altitude, inert and respiratory gas exchange and hemodynamic variables were studied at rest and during several levels of steady-state bicycle exercise. Multiple inert gas data from the previous and current studies were combined (after demonstrating no statistical difference between them) and showed increasing VA/Q inequality with sea level exercise (P = 0.02). Breathing 100% O2 did not reverse this increase. When O2 consumption exceeded about 2.7 1/min, evidence for DIFF at sea level was present (P = 0.01). VA/Q inequality and DIFF increased with exercise at altitude as found previously and was reversed by 100% O2 breathing. Indexes of VA/Q dispersion correlated well with mean pulmonary arterial pressure and also with minute ventilation. This study confirms the development of both VA/Q mismatch and DIFF in normal subjects during heavy exercise at sea level. However, the mechanism of increased VA/Q mismatch on exercise remains unclear due to the correlation with both ventilatory and circulatory variables and will require further study.

Duke Scholars

Published In

J Appl Physiol (1985)

DOI

ISSN

8750-7587

Publication Date

July 1986

Volume

61

Issue

1

Start / End Page

260 / 270

Location

United States

Related Subject Headings

  • Ventilation-Perfusion Ratio
  • Rest
  • Respiration
  • Pulmonary Gas Exchange
  • Pulmonary Alveoli
  • Physiology
  • Physical Exertion
  • Oxygen Consumption
  • Oxygen
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wagner, P. D., Gale, G. E., Moon, R. E., Torre-Bueno, J. R., Stolp, B. W., & Saltzman, H. A. (1986). Pulmonary gas exchange in humans exercising at sea level and simulated altitude. J Appl Physiol (1985), 61(1), 260–270. https://doi.org/10.1152/jappl.1986.61.1.260
Wagner, P. D., G. E. Gale, R. E. Moon, J. R. Torre-Bueno, B. W. Stolp, and H. A. Saltzman. “Pulmonary gas exchange in humans exercising at sea level and simulated altitude.J Appl Physiol (1985) 61, no. 1 (July 1986): 260–70. https://doi.org/10.1152/jappl.1986.61.1.260.
Wagner PD, Gale GE, Moon RE, Torre-Bueno JR, Stolp BW, Saltzman HA. Pulmonary gas exchange in humans exercising at sea level and simulated altitude. J Appl Physiol (1985). 1986 Jul;61(1):260–70.
Wagner, P. D., et al. “Pulmonary gas exchange in humans exercising at sea level and simulated altitude.J Appl Physiol (1985), vol. 61, no. 1, July 1986, pp. 260–70. Pubmed, doi:10.1152/jappl.1986.61.1.260.
Wagner PD, Gale GE, Moon RE, Torre-Bueno JR, Stolp BW, Saltzman HA. Pulmonary gas exchange in humans exercising at sea level and simulated altitude. J Appl Physiol (1985). 1986 Jul;61(1):260–270.

Published In

J Appl Physiol (1985)

DOI

ISSN

8750-7587

Publication Date

July 1986

Volume

61

Issue

1

Start / End Page

260 / 270

Location

United States

Related Subject Headings

  • Ventilation-Perfusion Ratio
  • Rest
  • Respiration
  • Pulmonary Gas Exchange
  • Pulmonary Alveoli
  • Physiology
  • Physical Exertion
  • Oxygen Consumption
  • Oxygen
  • Male