Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

Gene expression programs of human smooth muscle cells: tissue-specific differentiation and prognostic significance in breast cancers.

Publication ,  Journal Article
Chi, J-T; Rodriguez, EH; Wang, Z; Nuyten, DSA; Mukherjee, S; van de Rijn, M; van de Vijver, MJ; Hastie, T; Brown, PO
Published in: PLoS Genet
September 2007

Smooth muscle is present in a wide variety of anatomical locations, such as blood vessels, various visceral organs, and hair follicles. Contraction of smooth muscle is central to functions as diverse as peristalsis, urination, respiration, and the maintenance of vascular tone. Despite the varied physiological roles of smooth muscle cells (SMCs), we possess only a limited knowledge of the heterogeneity underlying their functional and anatomic specializations. As a step toward understanding the intrinsic differences between SMCs from different anatomical locations, we used DNA microarrays to profile global gene expression patterns in 36 SMC samples from various tissues after propagation under defined conditions in cell culture. Significant variations were found between the cells isolated from blood vessels, bronchi, and visceral organs. Furthermore, pervasive differences were noted within the visceral organ subgroups that appear to reflect the distinct molecular pathways essential for organogenesis as well as those involved in organ-specific contractile and physiological properties. Finally, we sought to understand how this diversity may contribute to SMC-involving pathology. We found that a gene expression signature of the responses of vascular SMCs to serum exposure is associated with a significantly poorer prognosis in human cancers, potentially linking vascular injury response to tumor progression.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

PLoS Genet

DOI

EISSN

1553-7404

Publication Date

September 2007

Volume

3

Issue

9

Start / End Page

1770 / 1784

Location

United States

Related Subject Headings

  • Promoter Regions, Genetic
  • Oligonucleotide Array Sequence Analysis
  • Muscle, Smooth, Vascular
  • Muscle, Smooth
  • Humans
  • Genes, Homeobox
  • Gene Expression Profiling
  • Gene Expression
  • Female
  • Endothelial Cells
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chi, J.-T., Rodriguez, E. H., Wang, Z., Nuyten, D. S. A., Mukherjee, S., van de Rijn, M., … Brown, P. O. (2007). Gene expression programs of human smooth muscle cells: tissue-specific differentiation and prognostic significance in breast cancers. PLoS Genet, 3(9), 1770–1784. https://doi.org/10.1371/journal.pgen.0030164
Chi, Jen-Tsan, Edwin H. Rodriguez, Zhen Wang, Dimitry S. A. Nuyten, Sayan Mukherjee, Matt van de Rijn, Marc J. van de Vijver, Trevor Hastie, and Patrick O. Brown. “Gene expression programs of human smooth muscle cells: tissue-specific differentiation and prognostic significance in breast cancers.PLoS Genet 3, no. 9 (September 2007): 1770–84. https://doi.org/10.1371/journal.pgen.0030164.
Chi J-T, Rodriguez EH, Wang Z, Nuyten DSA, Mukherjee S, van de Rijn M, et al. Gene expression programs of human smooth muscle cells: tissue-specific differentiation and prognostic significance in breast cancers. PLoS Genet. 2007 Sep;3(9):1770–84.
Chi, Jen-Tsan, et al. “Gene expression programs of human smooth muscle cells: tissue-specific differentiation and prognostic significance in breast cancers.PLoS Genet, vol. 3, no. 9, Sept. 2007, pp. 1770–84. Pubmed, doi:10.1371/journal.pgen.0030164.
Chi J-T, Rodriguez EH, Wang Z, Nuyten DSA, Mukherjee S, van de Rijn M, van de Vijver MJ, Hastie T, Brown PO. Gene expression programs of human smooth muscle cells: tissue-specific differentiation and prognostic significance in breast cancers. PLoS Genet. 2007 Sep;3(9):1770–1784.

Published In

PLoS Genet

DOI

EISSN

1553-7404

Publication Date

September 2007

Volume

3

Issue

9

Start / End Page

1770 / 1784

Location

United States

Related Subject Headings

  • Promoter Regions, Genetic
  • Oligonucleotide Array Sequence Analysis
  • Muscle, Smooth, Vascular
  • Muscle, Smooth
  • Humans
  • Genes, Homeobox
  • Gene Expression Profiling
  • Gene Expression
  • Female
  • Endothelial Cells