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Meningeal mycosis fungoides: clinical and cellular characteristics.

Publication ,  Journal Article
Hauch, TW; Shelbourne, JD; Cohen, HJ; Mason, D; Kremer, WB
Published in: Ann Intern Med
April 1975

A patient with mycosis fungoides developed meningeal disease while his skin disease was in remission with systemic chemotherapy. His central nervous system involvement with mycosis fungoides was controlled with intrathecal methotrexate for 7 months. The proliferating cells recovered from the spinal fluid showed similarities to the Sézary cell by light and electron microscopy. Surface receptor sutudies suggested that these cells were lymphoid cells of thymic derivation. Although mycosis fungoides has been shown to spread to the central nervous system in autopsied cases, reports of clinical neurologic disease are rare, and in only one earlier report have malignant cells have been found in the spinal fluid. Thus, as in other lymphoproliferative disorders, prompt consideration of meningeal involvement in a patient exhibiting neurologic symptoms while in peripheral remission may allow earlier treatment of this complication.

Duke Scholars

Published In

Ann Intern Med

DOI

ISSN

0003-4819

Publication Date

April 1975

Volume

82

Issue

4

Start / End Page

499 / 505

Location

United States

Related Subject Headings

  • Sheep
  • Neoplasms
  • Mycosis Fungoides
  • Middle Aged
  • Microscopy, Electron
  • Methotrexate
  • Meninges
  • Male
  • Immunoglobulins
  • Immune Adherence Reaction
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hauch, T. W., Shelbourne, J. D., Cohen, H. J., Mason, D., & Kremer, W. B. (1975). Meningeal mycosis fungoides: clinical and cellular characteristics. Ann Intern Med, 82(4), 499–505. https://doi.org/10.7326/0003-4819-82-4-499
Hauch, T. W., J. D. Shelbourne, H. J. Cohen, D. Mason, and W. B. Kremer. “Meningeal mycosis fungoides: clinical and cellular characteristics.Ann Intern Med 82, no. 4 (April 1975): 499–505. https://doi.org/10.7326/0003-4819-82-4-499.
Hauch TW, Shelbourne JD, Cohen HJ, Mason D, Kremer WB. Meningeal mycosis fungoides: clinical and cellular characteristics. Ann Intern Med. 1975 Apr;82(4):499–505.
Hauch, T. W., et al. “Meningeal mycosis fungoides: clinical and cellular characteristics.Ann Intern Med, vol. 82, no. 4, Apr. 1975, pp. 499–505. Pubmed, doi:10.7326/0003-4819-82-4-499.
Hauch TW, Shelbourne JD, Cohen HJ, Mason D, Kremer WB. Meningeal mycosis fungoides: clinical and cellular characteristics. Ann Intern Med. 1975 Apr;82(4):499–505.

Published In

Ann Intern Med

DOI

ISSN

0003-4819

Publication Date

April 1975

Volume

82

Issue

4

Start / End Page

499 / 505

Location

United States

Related Subject Headings

  • Sheep
  • Neoplasms
  • Mycosis Fungoides
  • Middle Aged
  • Microscopy, Electron
  • Methotrexate
  • Meninges
  • Male
  • Immunoglobulins
  • Immune Adherence Reaction