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Secretory leukocyte protease inhibitor blocks infectivity of primary monocytes and mononuclear cells with both monocytotropic and lymphocytotropic strains of human immunodeficiency virus type I.

Publication ,  Journal Article
Shugars, DC; Sauls, DL; Weinberg, JB
Published in: Oral Dis
May 1997

Saliva contains factors that inhibit infection with the human immunodeficiency virus type 1 (HIV-1) in vitro. One of these factors was recently identified as secretory leukocyte protease inhibitor (SLPI), a salivary protein which blocked HIV-1 infectivity of monocytes and primary T cells at physiologic concentrations (J Clin Invest 1995; 96: 456). Here, we confirm and extend the original report by demonstrating that SLPI protects primary monocytes and peripheral blood mononuclear cells against infection with HIV-1 Ba-L, IIIB and NL4-3. Thus, SLPI may provide a natural barrier against oral transmission of HIV-1.

Duke Scholars

Published In

Oral Dis

DOI

ISSN

1354-523X

Publication Date

May 1997

Volume

3 Suppl 1

Start / End Page

S70 / S72

Location

Denmark

Related Subject Headings

  • Virulence
  • Serine Proteinase Inhibitors
  • Secretory Leukocyte Peptidase Inhibitor
  • Salivary Proteins and Peptides
  • Proteins
  • Proteinase Inhibitory Proteins, Secretory
  • Monocytes
  • Leukocytes, Mononuclear
  • Humans
  • HIV-1
 

Citation

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ICMJE
MLA
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Shugars, D. C., Sauls, D. L., & Weinberg, J. B. (1997). Secretory leukocyte protease inhibitor blocks infectivity of primary monocytes and mononuclear cells with both monocytotropic and lymphocytotropic strains of human immunodeficiency virus type I. Oral Dis, 3 Suppl 1, S70–S72. https://doi.org/10.1111/j.1601-0825.1997.tb00379.x
Shugars, D. C., D. L. Sauls, and J. B. Weinberg. “Secretory leukocyte protease inhibitor blocks infectivity of primary monocytes and mononuclear cells with both monocytotropic and lymphocytotropic strains of human immunodeficiency virus type I.Oral Dis 3 Suppl 1 (May 1997): S70–72. https://doi.org/10.1111/j.1601-0825.1997.tb00379.x.
Journal cover image

Published In

Oral Dis

DOI

ISSN

1354-523X

Publication Date

May 1997

Volume

3 Suppl 1

Start / End Page

S70 / S72

Location

Denmark

Related Subject Headings

  • Virulence
  • Serine Proteinase Inhibitors
  • Secretory Leukocyte Peptidase Inhibitor
  • Salivary Proteins and Peptides
  • Proteins
  • Proteinase Inhibitory Proteins, Secretory
  • Monocytes
  • Leukocytes, Mononuclear
  • Humans
  • HIV-1