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Nitric oxide, malaria, and anemia: inverse relationship between nitric oxide production and hemoglobin concentration in asymptomatic, malaria-exposed children.

Publication ,  Journal Article
Anstey, NM; Granger, DL; Hassanali, MY; Mwaikambo, ED; Duffy, PE; Weinberg, JB
Published in: Am J Trop Med Hyg
August 1999

The cause of the anemia associated with chronic, intermittent, asymptomatic, low-level parasitemia in children in malaria-endemic endemic areas is not well understood. Nitric oxide (NO) decreases erythropoiesis, and it is likely an important mediator of anemia of chronic disease. Production of NO is decreased in acute uncomplicated and cerebral malaria, but it is increased in asymptomatic Tanzanian children (with or without parasitemia). We hypothesized that chronic overproduction of NO in these asymptomatic children contributes to the anemia associated with subclinical/subpatent malaria. In 44 fasting, asymptomatic, malaria-exposed, Tanzanian children, NO production (measured using fasting urine NOx excretion) was inversely associated with hemoglobin concentration (P = 0.03, controlling for age and gender). Using multiple linear regression, hemoglobin concentration was negatively associated with parasitemia (P = 0.005). After controlling for age and parasitemia, NO was no longer an independent predictor of anemia. One of the mechanisms of parasite-related anemia in such children may be through the adverse hematologic effects of parasite-induced NO production.

Duke Scholars

Published In

Am J Trop Med Hyg

DOI

ISSN

0002-9637

Publication Date

August 1999

Volume

61

Issue

2

Start / End Page

249 / 252

Location

United States

Related Subject Headings

  • Tropical Medicine
  • Tanzania
  • Prospective Studies
  • Parasitemia
  • Nitric Oxide
  • Male
  • Malaria
  • Linear Models
  • Infant
  • Humans
 

Citation

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Anstey, N. M., Granger, D. L., Hassanali, M. Y., Mwaikambo, E. D., Duffy, P. E., & Weinberg, J. B. (1999). Nitric oxide, malaria, and anemia: inverse relationship between nitric oxide production and hemoglobin concentration in asymptomatic, malaria-exposed children. Am J Trop Med Hyg, 61(2), 249–252. https://doi.org/10.4269/ajtmh.1999.61.249
Anstey, N. M., D. L. Granger, M. Y. Hassanali, E. D. Mwaikambo, P. E. Duffy, and J. B. Weinberg. “Nitric oxide, malaria, and anemia: inverse relationship between nitric oxide production and hemoglobin concentration in asymptomatic, malaria-exposed children.Am J Trop Med Hyg 61, no. 2 (August 1999): 249–52. https://doi.org/10.4269/ajtmh.1999.61.249.
Anstey NM, Granger DL, Hassanali MY, Mwaikambo ED, Duffy PE, Weinberg JB. Nitric oxide, malaria, and anemia: inverse relationship between nitric oxide production and hemoglobin concentration in asymptomatic, malaria-exposed children. Am J Trop Med Hyg. 1999 Aug;61(2):249–52.
Anstey, N. M., et al. “Nitric oxide, malaria, and anemia: inverse relationship between nitric oxide production and hemoglobin concentration in asymptomatic, malaria-exposed children.Am J Trop Med Hyg, vol. 61, no. 2, Aug. 1999, pp. 249–52. Pubmed, doi:10.4269/ajtmh.1999.61.249.
Anstey NM, Granger DL, Hassanali MY, Mwaikambo ED, Duffy PE, Weinberg JB. Nitric oxide, malaria, and anemia: inverse relationship between nitric oxide production and hemoglobin concentration in asymptomatic, malaria-exposed children. Am J Trop Med Hyg. 1999 Aug;61(2):249–252.

Published In

Am J Trop Med Hyg

DOI

ISSN

0002-9637

Publication Date

August 1999

Volume

61

Issue

2

Start / End Page

249 / 252

Location

United States

Related Subject Headings

  • Tropical Medicine
  • Tanzania
  • Prospective Studies
  • Parasitemia
  • Nitric Oxide
  • Male
  • Malaria
  • Linear Models
  • Infant
  • Humans