Tumor cell killing by phorbol ester--differentiated human leukemia cells.
Publication
, Journal Article
Weinberg, JB
Published in: Science
August 7, 1981
The tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate causes differentiation of cells of the human leukemia cell line HL60 to nondividing macrophage-like cells. These differentiated cells are cytotoxic for tumor cells (including parent, untreated HL60 cells) in vitro. Agents that induce this desirable differentiation to nondividing, antitumor effector cells may be useful in the experimental treatment of leukemia.
Duke Scholars
Published In
Science
DOI
ISSN
0036-8075
Publication Date
August 7, 1981
Volume
213
Issue
4508
Start / End Page
655 / 657
Location
United States
Related Subject Headings
- Tetradecanoylphorbol Acetate
- Phorbols
- Macrophages
- Leukemia, Experimental
- Immunity, Cellular
- Humans
- General Science & Technology
- Cytotoxicity, Immunologic
- Cell Line
- Cell Differentiation
Citation
APA
Chicago
ICMJE
MLA
NLM
Weinberg, J. B. (1981). Tumor cell killing by phorbol ester--differentiated human leukemia cells. Science, 213(4508), 655–657. https://doi.org/10.1126/science.7196085
Weinberg, J. B. “Tumor cell killing by phorbol ester--differentiated human leukemia cells.” Science 213, no. 4508 (August 7, 1981): 655–57. https://doi.org/10.1126/science.7196085.
Weinberg JB. Tumor cell killing by phorbol ester--differentiated human leukemia cells. Science. 1981 Aug 7;213(4508):655–7.
Weinberg, J. B. “Tumor cell killing by phorbol ester--differentiated human leukemia cells.” Science, vol. 213, no. 4508, Aug. 1981, pp. 655–57. Pubmed, doi:10.1126/science.7196085.
Weinberg JB. Tumor cell killing by phorbol ester--differentiated human leukemia cells. Science. 1981 Aug 7;213(4508):655–657.
Published In
Science
DOI
ISSN
0036-8075
Publication Date
August 7, 1981
Volume
213
Issue
4508
Start / End Page
655 / 657
Location
United States
Related Subject Headings
- Tetradecanoylphorbol Acetate
- Phorbols
- Macrophages
- Leukemia, Experimental
- Immunity, Cellular
- Humans
- General Science & Technology
- Cytotoxicity, Immunologic
- Cell Line
- Cell Differentiation