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Macrophage tumor killing: influence of the local environment.

Publication ,  Journal Article
Hibbs, JB; Taintor, RR; Chapman, HA; Weinberg, JB
Published in: Science (New York, N.Y.)
July 1977
Published version (DOI)

Tumor killing by activated macrophages is not a highly determined biologic event, but a relative capability influenced by the local environment. An intrinsic macrophage cytotoxic effector system is modulated by serum and other environmental factors that can either enhance or suppress tumor killing. Activated macrophages kill tumor cells only when a regulating threshold drops to a critically low level.

Duke Scholars

Joe Brice Weinberg
Author Joe Brice Weinberg Medicine, Hematology

Published In

Science (New York, N.Y.)

DOI

10.1126/science.327547

EISSN

1095-9203

ISSN

0036-8075

Publication Date

July 1977

Volume

197

Issue

4300

Start / End Page

279 / 282

Related Subject Headings

  • Trypsin
  • Toxoplasma
  • Neoplasms, Experimental
  • Mycobacterium bovis
  • Macrophages
  • Lymphokines
  • General Science & Technology
  • Enzyme Inhibitors
  • Endotoxins
  • Culture Media
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hibbs, J. B., Taintor, R. R., Chapman, H. A., & Weinberg, J. B. (1977). Macrophage tumor killing: influence of the local environment. Science (New York, N.Y.), 197(4300), 279–282. https://doi.org/10.1126/science.327547
Hibbs, J. B., R. R. Taintor, H. A. Chapman, and J. B. Weinberg. “Macrophage tumor killing: influence of the local environment.” Science (New York, N.Y.) 197, no. 4300 (July 1977): 279–82. https://doi.org/10.1126/science.327547.
Hibbs JB, Taintor RR, Chapman HA, Weinberg JB. Macrophage tumor killing: influence of the local environment. Science (New York, NY). 1977 Jul;197(4300):279–82.
Hibbs, J. B., et al. “Macrophage tumor killing: influence of the local environment.” Science (New York, N.Y.), vol. 197, no. 4300, July 1977, pp. 279–82. Epmc, doi:10.1126/science.327547.
Hibbs JB, Taintor RR, Chapman HA, Weinberg JB. Macrophage tumor killing: influence of the local environment. Science (New York, NY). 1977 Jul;197(4300):279–282.
Journal cover image

Published In

Science (New York, N.Y.)

DOI

10.1126/science.327547

EISSN

1095-9203

ISSN

0036-8075

Publication Date

July 1977

Volume

197

Issue

4300

Start / End Page

279 / 282

Related Subject Headings

  • Trypsin
  • Toxoplasma
  • Neoplasms, Experimental
  • Mycobacterium bovis
  • Macrophages
  • Lymphokines
  • General Science & Technology
  • Enzyme Inhibitors
  • Endotoxins
  • Culture Media