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Orphan nuclear receptors in T lymphocyte development.

Publication ,  Journal Article
He, Y-W
Published in: J Leukoc Biol
September 2002

Lymphocyte development is initiated from hematopoietic stem cells and can be divided into multiple phenotypically distinct stages. Transcription factors play important roles in programming the developmental process of lymphocytes. Recent studies have identified key roles of several orphan nuclear receptors in T lymphocyte development. The orphan nuclear receptor RORgamma has been shown to promote thymocyte survival by activating the expression of antiapoptotic protein Bcl-x(L). RORgamma is also required for the development of lymph nodes and Peyer's patches. The orphan receptors Nur77 and Nor1 are involved in TCR-mediated cell death and thymocyte-negative selection. These studies provide novel insights into the molecular mechanisms of T lymphocyte development.

Duke Scholars

Published In

J Leukoc Biol

ISSN

0741-5400

Publication Date

September 2002

Volume

72

Issue

3

Start / End Page

440 / 446

Location

England

Related Subject Headings

  • bcl-X Protein
  • Transcription Factors
  • Thymus Gland
  • T-Lymphocytes
  • Receptors, Thyroid Hormone
  • Receptors, Steroid
  • Receptors, Retinoic Acid
  • Receptors, Cytoplasmic and Nuclear
  • Rats
  • Proto-Oncogene Proteins c-bcl-2
 

Citation

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ICMJE
MLA
NLM
He, Y.-W. (2002). Orphan nuclear receptors in T lymphocyte development. J Leukoc Biol, 72(3), 440–446.
He, You-Wen. “Orphan nuclear receptors in T lymphocyte development.J Leukoc Biol 72, no. 3 (September 2002): 440–46.
He Y-W. Orphan nuclear receptors in T lymphocyte development. J Leukoc Biol. 2002 Sep;72(3):440–6.
He, You-Wen. “Orphan nuclear receptors in T lymphocyte development.J Leukoc Biol, vol. 72, no. 3, Sept. 2002, pp. 440–46.
He Y-W. Orphan nuclear receptors in T lymphocyte development. J Leukoc Biol. 2002 Sep;72(3):440–446.

Published In

J Leukoc Biol

ISSN

0741-5400

Publication Date

September 2002

Volume

72

Issue

3

Start / End Page

440 / 446

Location

England

Related Subject Headings

  • bcl-X Protein
  • Transcription Factors
  • Thymus Gland
  • T-Lymphocytes
  • Receptors, Thyroid Hormone
  • Receptors, Steroid
  • Receptors, Retinoic Acid
  • Receptors, Cytoplasmic and Nuclear
  • Rats
  • Proto-Oncogene Proteins c-bcl-2