In vitro and in vivo genotoxicity evaluation of hormonal drugs. I. Hydrocortisone.
Publication
, Journal Article
Bali, D; Singh, JR; Singh, H; Sandhu, D
Published in: Environ Mol Mutagen
1990
Genotoxic evaluation of a widely used glucocorticoid, hydrocortisone, was undertaken using a battery of in vitro and in vivo test systems. Human lymphocyte cultures and mouse bone marrow studies (micronuclei and sister chromatid exchange analyses) showed the drug to be very potent clastogen. However, the Ames/Salmonella assay both with and without S9 did not show an increase in the His+ revertants.
Duke Scholars
Published In
Environ Mol Mutagen
DOI
ISSN
0893-6692
Publication Date
1990
Volume
16
Issue
4
Start / End Page
250 / 254
Location
United States
Related Subject Headings
- Toxicology
- Sister Chromatid Exchange
- Mutagens
- Mutagenicity Tests
- Micronucleus Tests
- Mice
- Male
- Hydrocortisone
- Humans
- Chromosome Aberrations
Citation
APA
Chicago
ICMJE
MLA
NLM
Bali, D., Singh, J. R., Singh, H., & Sandhu, D. (1990). In vitro and in vivo genotoxicity evaluation of hormonal drugs. I. Hydrocortisone. Environ Mol Mutagen, 16(4), 250–254. https://doi.org/10.1002/em.2850160406
Bali, D., J. R. Singh, H. Singh, and D. Sandhu. “In vitro and in vivo genotoxicity evaluation of hormonal drugs. I. Hydrocortisone.” Environ Mol Mutagen 16, no. 4 (1990): 250–54. https://doi.org/10.1002/em.2850160406.
Bali D, Singh JR, Singh H, Sandhu D. In vitro and in vivo genotoxicity evaluation of hormonal drugs. I. Hydrocortisone. Environ Mol Mutagen. 1990;16(4):250–4.
Bali, D., et al. “In vitro and in vivo genotoxicity evaluation of hormonal drugs. I. Hydrocortisone.” Environ Mol Mutagen, vol. 16, no. 4, 1990, pp. 250–54. Pubmed, doi:10.1002/em.2850160406.
Bali D, Singh JR, Singh H, Sandhu D. In vitro and in vivo genotoxicity evaluation of hormonal drugs. I. Hydrocortisone. Environ Mol Mutagen. 1990;16(4):250–254.
Published In
Environ Mol Mutagen
DOI
ISSN
0893-6692
Publication Date
1990
Volume
16
Issue
4
Start / End Page
250 / 254
Location
United States
Related Subject Headings
- Toxicology
- Sister Chromatid Exchange
- Mutagens
- Mutagenicity Tests
- Micronucleus Tests
- Mice
- Male
- Hydrocortisone
- Humans
- Chromosome Aberrations