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Gastrointestinal toxicity of transperineal interstitial prostate brachytherapy.

Publication ,  Journal Article
Kang, SK; Chou, RH; Dodge, RK; Clough, RW; Kang, H-SL; Hahn, CA; Whitehurst, AW; Buckley, NJ; Kim, JH; Joyner, RE; Montana, GS; Ingram, SS ...
Published in: Int J Radiat Oncol Biol Phys
May 1, 2002

PURPOSE: To characterize the severity and time course of rectal toxicity following transperineal prostate brachytherapy using prospectively recorded data, and to determine factors associated with toxicity. METHODS AND MATERIALS: One hundred thirty-four patients with prostate cancer treated with transperineal brachytherapy from 1997 to 1999 had rectal toxicity data available for analysis. Patients with Gleason score (GS) > 6, prostate-specific antigen (PSA) > 6, or stage > T2a were treated initially with external beam radiation therapy followed by brachytherapy boost; patients with none of these features were treated with brachytherapy alone. Both iodine-125 and palladium-103 sources were used, and loaded according to a modified Quimby distribution. At each follow-up, toxicity was recorded according to a modified RTOG gastrointestinal scale. RESULTS: Thirty-nine percent of patients experienced gastrointestinal toxicity, mostly Grade 1. Median duration of symptoms was 6 months. Two patients experienced Grade 3 toxicity, both of whom had minimal symptoms until their 12-month follow-up. There was no Grade 4 or 5 toxicity. The addition of external beam radiation therapy (p = 0.003), higher clinical stage (p = 0.006), and Caucasian race (p = 0.01) were associated with increased incidence of toxicity. CONCLUSION: Most patients with rectal toxicity have very mild symptoms. There is a small risk of severe late toxicity. External beam radiation, higher stage, and race are associated with toxicity.

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Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

May 1, 2002

Volume

53

Issue

1

Start / End Page

99 / 103

Location

United States

Related Subject Headings

  • Regression Analysis
  • Rectal Diseases
  • Radioisotopes
  • Radiation Injuries
  • Prostatic Neoplasms
  • Prostate-Specific Antigen
  • Prospective Studies
  • Palladium
  • Oncology & Carcinogenesis
  • Middle Aged
 

Citation

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Kang, S. K., Chou, R. H., Dodge, R. K., Clough, R. W., Kang, H.-S., Hahn, C. A., … Anscher, M. S. (2002). Gastrointestinal toxicity of transperineal interstitial prostate brachytherapy. Int J Radiat Oncol Biol Phys, 53(1), 99–103. https://doi.org/10.1016/s0360-3016(01)02811-5
Kang, Song K., Rachel H. Chou, Richard K. Dodge, Robert W. Clough, Hi-Sung L. Kang, Carol A. Hahn, Arthur W. Whitehurst, et al. “Gastrointestinal toxicity of transperineal interstitial prostate brachytherapy.Int J Radiat Oncol Biol Phys 53, no. 1 (May 1, 2002): 99–103. https://doi.org/10.1016/s0360-3016(01)02811-5.
Kang SK, Chou RH, Dodge RK, Clough RW, Kang H-SL, Hahn CA, et al. Gastrointestinal toxicity of transperineal interstitial prostate brachytherapy. Int J Radiat Oncol Biol Phys. 2002 May 1;53(1):99–103.
Kang, Song K., et al. “Gastrointestinal toxicity of transperineal interstitial prostate brachytherapy.Int J Radiat Oncol Biol Phys, vol. 53, no. 1, May 2002, pp. 99–103. Pubmed, doi:10.1016/s0360-3016(01)02811-5.
Kang SK, Chou RH, Dodge RK, Clough RW, Kang H-SL, Hahn CA, Whitehurst AW, Buckley NJ, Kim JH, Joyner RE, Montana GS, Ingram SS, Anscher MS. Gastrointestinal toxicity of transperineal interstitial prostate brachytherapy. Int J Radiat Oncol Biol Phys. 2002 May 1;53(1):99–103.
Journal cover image

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

May 1, 2002

Volume

53

Issue

1

Start / End Page

99 / 103

Location

United States

Related Subject Headings

  • Regression Analysis
  • Rectal Diseases
  • Radioisotopes
  • Radiation Injuries
  • Prostatic Neoplasms
  • Prostate-Specific Antigen
  • Prospective Studies
  • Palladium
  • Oncology & Carcinogenesis
  • Middle Aged