Pathophysiology of SPINK mutations in pancreatic development and disease.
Publication
, Journal Article
Liddle, RA
Published in: Endocrinol Metab Clin North Am
June 2006
The endogenous pancreatic trypsin inhibitor, SPINK, is believed to limit enzyme activity in the pancreas and reduce the risk of pancreatitis. Recently, mutations in the SPINK1 gene have been associated with development of both acute and chronic pancreatitis. In most patients with SPINK1 mutations, the genetic variants do not cause the disease independently, but may act in concert with other genetic or environmental factors. Recent studies, using mice in which the trypsin inhibitor gene has been deleted or overexpressed, provide novel insights into the role of SPINK in pancreatic development and pancreatitis.
Duke Scholars
Published In
Endocrinol Metab Clin North Am
DOI
ISSN
0889-8529
Publication Date
June 2006
Volume
35
Issue
2
Start / End Page
345 / x
Location
United States
Related Subject Headings
- Trypsinogen
- Trypsin Inhibitor, Kazal Pancreatic
- Point Mutation
- Pancreatitis
- Mice, Knockout
- Mice
- Humans
- Genetic Predisposition to Disease
- Enzyme Activation
- Endocrinology & Metabolism
Citation
APA
Chicago
ICMJE
MLA
NLM
Liddle, R. A. (2006). Pathophysiology of SPINK mutations in pancreatic development and disease. Endocrinol Metab Clin North Am, 35(2), 345–x. https://doi.org/10.1016/j.ecl.2006.02.012
Liddle, Rodger A. “Pathophysiology of SPINK mutations in pancreatic development and disease.” Endocrinol Metab Clin North Am 35, no. 2 (June 2006): 345–x. https://doi.org/10.1016/j.ecl.2006.02.012.
Liddle RA. Pathophysiology of SPINK mutations in pancreatic development and disease. Endocrinol Metab Clin North Am. 2006 Jun;35(2):345–x.
Liddle, Rodger A. “Pathophysiology of SPINK mutations in pancreatic development and disease.” Endocrinol Metab Clin North Am, vol. 35, no. 2, June 2006, pp. 345–x. Pubmed, doi:10.1016/j.ecl.2006.02.012.
Liddle RA. Pathophysiology of SPINK mutations in pancreatic development and disease. Endocrinol Metab Clin North Am. 2006 Jun;35(2):345–x.
Published In
Endocrinol Metab Clin North Am
DOI
ISSN
0889-8529
Publication Date
June 2006
Volume
35
Issue
2
Start / End Page
345 / x
Location
United States
Related Subject Headings
- Trypsinogen
- Trypsin Inhibitor, Kazal Pancreatic
- Point Mutation
- Pancreatitis
- Mice, Knockout
- Mice
- Humans
- Genetic Predisposition to Disease
- Enzyme Activation
- Endocrinology & Metabolism