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Pathophysiology of SPINK mutations in pancreatic development and disease.

Publication ,  Journal Article
Liddle, RA
Published in: Endocrinol Metab Clin North Am
June 2006

The endogenous pancreatic trypsin inhibitor, SPINK, is believed to limit enzyme activity in the pancreas and reduce the risk of pancreatitis. Recently, mutations in the SPINK1 gene have been associated with development of both acute and chronic pancreatitis. In most patients with SPINK1 mutations, the genetic variants do not cause the disease independently, but may act in concert with other genetic or environmental factors. Recent studies, using mice in which the trypsin inhibitor gene has been deleted or overexpressed, provide novel insights into the role of SPINK in pancreatic development and pancreatitis.

Duke Scholars

Published In

Endocrinol Metab Clin North Am

DOI

ISSN

0889-8529

Publication Date

June 2006

Volume

35

Issue

2

Start / End Page

345 / x

Location

United States

Related Subject Headings

  • Trypsinogen
  • Trypsin Inhibitor, Kazal Pancreatic
  • Point Mutation
  • Pancreatitis
  • Mice, Knockout
  • Mice
  • Humans
  • Genetic Predisposition to Disease
  • Enzyme Activation
  • Endocrinology & Metabolism
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Liddle, R. A. (2006). Pathophysiology of SPINK mutations in pancreatic development and disease. Endocrinol Metab Clin North Am, 35(2), 345–x. https://doi.org/10.1016/j.ecl.2006.02.012
Liddle, Rodger A. “Pathophysiology of SPINK mutations in pancreatic development and disease.Endocrinol Metab Clin North Am 35, no. 2 (June 2006): 345–x. https://doi.org/10.1016/j.ecl.2006.02.012.
Liddle RA. Pathophysiology of SPINK mutations in pancreatic development and disease. Endocrinol Metab Clin North Am. 2006 Jun;35(2):345–x.
Liddle, Rodger A. “Pathophysiology of SPINK mutations in pancreatic development and disease.Endocrinol Metab Clin North Am, vol. 35, no. 2, June 2006, pp. 345–x. Pubmed, doi:10.1016/j.ecl.2006.02.012.
Liddle RA. Pathophysiology of SPINK mutations in pancreatic development and disease. Endocrinol Metab Clin North Am. 2006 Jun;35(2):345–x.
Journal cover image

Published In

Endocrinol Metab Clin North Am

DOI

ISSN

0889-8529

Publication Date

June 2006

Volume

35

Issue

2

Start / End Page

345 / x

Location

United States

Related Subject Headings

  • Trypsinogen
  • Trypsin Inhibitor, Kazal Pancreatic
  • Point Mutation
  • Pancreatitis
  • Mice, Knockout
  • Mice
  • Humans
  • Genetic Predisposition to Disease
  • Enzyme Activation
  • Endocrinology & Metabolism