Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B.
Publication
, Journal Article
Keinan, S; Paquette, WD; Skoko, JJ; Beratan, DN; Yang, W; Shinde, S; Johnston, PA; Lazo, JS; Wipf, P
Published in: Organic & biomolecular chemistry
September 2008
Quinoid inhibitors of Cdc25B were designed based on the Linear Combination of Atomic Potentials (LCAP) methodology. In contrast to a published hypothesis, the biological activities and hydrogen peroxide generation in reducing media of three synthetic models did not correlate with the quinone half-wave potential, E(1/2).
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Published In
Organic & biomolecular chemistry
DOI
EISSN
1477-0539
ISSN
1477-0520
Publication Date
September 2008
Volume
6
Issue
18
Start / End Page
3256 / 3263
Related Subject Headings
- cdc25 Phosphatases
- Substrate Specificity
- Structure-Activity Relationship
- Quinones
- Oxidation-Reduction
- Organic Chemistry
- Molecular Structure
- Hydrogen Peroxide
- Humans
- Enzyme Inhibitors
Citation
APA
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ICMJE
MLA
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Keinan, S., Paquette, W. D., Skoko, J. J., Beratan, D. N., Yang, W., Shinde, S., … Wipf, P. (2008). Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B. Organic & Biomolecular Chemistry, 6(18), 3256–3263. https://doi.org/10.1039/b806712k
Keinan, Shahar, William D. Paquette, John J. Skoko, David N. Beratan, Weitao Yang, Sunita Shinde, Paul A. Johnston, John S. Lazo, and Peter Wipf. “Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B.” Organic & Biomolecular Chemistry 6, no. 18 (September 2008): 3256–63. https://doi.org/10.1039/b806712k.
Keinan S, Paquette WD, Skoko JJ, Beratan DN, Yang W, Shinde S, et al. Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B. Organic & biomolecular chemistry. 2008 Sep;6(18):3256–63.
Keinan, Shahar, et al. “Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B.” Organic & Biomolecular Chemistry, vol. 6, no. 18, Sept. 2008, pp. 3256–63. Epmc, doi:10.1039/b806712k.
Keinan S, Paquette WD, Skoko JJ, Beratan DN, Yang W, Shinde S, Johnston PA, Lazo JS, Wipf P. Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B. Organic & biomolecular chemistry. 2008 Sep;6(18):3256–3263.
Published In
Organic & biomolecular chemistry
DOI
EISSN
1477-0539
ISSN
1477-0520
Publication Date
September 2008
Volume
6
Issue
18
Start / End Page
3256 / 3263
Related Subject Headings
- cdc25 Phosphatases
- Substrate Specificity
- Structure-Activity Relationship
- Quinones
- Oxidation-Reduction
- Organic Chemistry
- Molecular Structure
- Hydrogen Peroxide
- Humans
- Enzyme Inhibitors