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Randomized comparison of the cost and effectiveness of iopamidol and diatrizoate as contrast agents for cardiac angiography.

Publication ,  Journal Article
Hlatky, MA; Morris, KG; Pieper, KS; Davidson, CJ; Schwab, SJ; Bashore, TM
Published in: J Am Coll Cardiol
October 1990

To evaluate the effectiveness and cost of low osmolarity, nonionic contrast agents for cardiac angiography, 443 patients were randomized to receive either iopamidol or diatrizoate. All adverse events that occurred within 24 h of the procedure were recorded prospectively by study personnel and classified according to previously determined criteria. Major events were defined as life threatening or requiring a procedure to treat, or both. Costs of the catheterization procedure, pharmacy, hospital laboratory and treatment of adverse events were determined on the basis of actual resource use. A total of 20 patients (8.5%) had major and 143 (61%) had minor adverse events with diatrizoate use; 10 patients (4.8%) had major and 53 (25%) had minor adverse events with iopamidol (p = 0.12 for major events; p less than 0.001 for total events). Most adverse events were treated fairly easily and inexpensively. The median overall cost was $186 higher for patients after iopamidol use compared with diatrizoate (p less than 0.0001), but all costs except the cost of the contrast agent were not significantly different between the two groups. Thus, patients who received iopamidol for cardiac angiography had a significantly lower rate of adverse events than those who received diatrizoate, but this difference was achieved at a considerably high overall cost.

Duke Scholars

Published In

J Am Coll Cardiol

DOI

ISSN

0735-1097

Publication Date

October 1990

Volume

16

Issue

4

Start / End Page

871 / 877

Location

United States

Related Subject Headings

  • Risk Factors
  • Middle Aged
  • Male
  • Iopamidol
  • Humans
  • Female
  • Diatrizoate
  • Costs and Cost Analysis
  • Cost-Benefit Analysis
  • Cardiovascular System & Hematology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hlatky, M. A., Morris, K. G., Pieper, K. S., Davidson, C. J., Schwab, S. J., & Bashore, T. M. (1990). Randomized comparison of the cost and effectiveness of iopamidol and diatrizoate as contrast agents for cardiac angiography. J Am Coll Cardiol, 16(4), 871–877. https://doi.org/10.1016/s0735-1097(10)80335-3
Hlatky, M. A., K. G. Morris, K. S. Pieper, C. J. Davidson, S. J. Schwab, and T. M. Bashore. “Randomized comparison of the cost and effectiveness of iopamidol and diatrizoate as contrast agents for cardiac angiography.J Am Coll Cardiol 16, no. 4 (October 1990): 871–77. https://doi.org/10.1016/s0735-1097(10)80335-3.
Hlatky MA, Morris KG, Pieper KS, Davidson CJ, Schwab SJ, Bashore TM. Randomized comparison of the cost and effectiveness of iopamidol and diatrizoate as contrast agents for cardiac angiography. J Am Coll Cardiol. 1990 Oct;16(4):871–7.
Hlatky, M. A., et al. “Randomized comparison of the cost and effectiveness of iopamidol and diatrizoate as contrast agents for cardiac angiography.J Am Coll Cardiol, vol. 16, no. 4, Oct. 1990, pp. 871–77. Pubmed, doi:10.1016/s0735-1097(10)80335-3.
Hlatky MA, Morris KG, Pieper KS, Davidson CJ, Schwab SJ, Bashore TM. Randomized comparison of the cost and effectiveness of iopamidol and diatrizoate as contrast agents for cardiac angiography. J Am Coll Cardiol. 1990 Oct;16(4):871–877.
Journal cover image

Published In

J Am Coll Cardiol

DOI

ISSN

0735-1097

Publication Date

October 1990

Volume

16

Issue

4

Start / End Page

871 / 877

Location

United States

Related Subject Headings

  • Risk Factors
  • Middle Aged
  • Male
  • Iopamidol
  • Humans
  • Female
  • Diatrizoate
  • Costs and Cost Analysis
  • Cost-Benefit Analysis
  • Cardiovascular System & Hematology