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Combination therapy of zonisamide and bupropion for weight reduction in obese women: a preliminary, randomized, open-label study.

Publication ,  Journal Article
Gadde, KM; Yonish, GM; Foust, MS; Wagner, HR
Published in: J Clin Psychiatry
August 2007

OBJECTIVE: Zonisamide and bupropion have been investigated for weight reduction in obese adults. We conducted a preliminary study comparing the effect on body weight of the combination of these 2 drugs versus zonisamide monotherapy. METHOD: This was a 12-week, randomized, open-label, parallel-group comparison of 2 active interventions conducted from October 2003 to June 2004. Eighteen obese women (mean [SE] body mass index of 36.8 [1.2] kg/m(2)) were randomly assigned to receive the combination of zonisamide and bupropion (N = 9) or zonisamide alone (N = 9). All subjects were prescribed a balanced hypocaloric diet (500 kcal/day deficit) and compliance was monitored with self-rated food diaries. Zonisamide therapy was started at 100 mg/day, with a gradual increase to 400 mg/day over 4 weeks for both groups. In addition, the group assigned to combination therapy received bupropion, which was started at 100 mg/day, with an increase to 200 mg/day after 2 weeks. Zonisamide was administered at night and bupropion in the morning. Body weight in kilograms was the primary outcome measure. RESULTS: In an intent-to-treat analysis, carrying the last observation forward for all randomly assigned participants with at least 1 postbaseline assessment, the combination group lost more body weight than the zonisamide group (mean [SE] = 7.2 [1.2] kg [7.5%] vs. 2.9 [0.7] kg [3.1%]; F = 4.7, df = 4,56; p = .003) during the 12-week period. For the subset of 12 patients (combination, N = 7; zonisamide, N = 5) that completed the full 12-week treatment, the mean (SE) weight loss was 8.1 (1.4) kg (8.5%) for the combination group versus 3.0 (0.9) kg (3.3%) for the zonisamide group (F = 4.6, df = 4,40; p = .004). Six subjects in the combination group and 2 in the zonisamide group lost at least 5% of body weight. CONCLUSION: In this short-term, open-label, preliminary trial, combination treatment of zonisamide and bupropion resulted in more weight loss than treatment with zonisamide alone.

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Published In

J Clin Psychiatry

DOI

EISSN

1555-2101

Publication Date

August 2007

Volume

68

Issue

8

Start / End Page

1226 / 1229

Location

United States

Related Subject Headings

  • Zonisamide
  • Weight Loss
  • Waist-Hip Ratio
  • Treatment Outcome
  • Psychiatry
  • Obesity
  • Isoxazoles
  • Humans
  • Female
  • Drug Therapy, Combination
 

Citation

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Gadde, K. M., Yonish, G. M., Foust, M. S., & Wagner, H. R. (2007). Combination therapy of zonisamide and bupropion for weight reduction in obese women: a preliminary, randomized, open-label study. J Clin Psychiatry, 68(8), 1226–1229. https://doi.org/10.4088/jcp.v68n0809
Gadde, Kishore M., Gretchen M. Yonish, Mariko S. Foust, and H Ryan Wagner. “Combination therapy of zonisamide and bupropion for weight reduction in obese women: a preliminary, randomized, open-label study.J Clin Psychiatry 68, no. 8 (August 2007): 1226–29. https://doi.org/10.4088/jcp.v68n0809.
Gadde KM, Yonish GM, Foust MS, Wagner HR. Combination therapy of zonisamide and bupropion for weight reduction in obese women: a preliminary, randomized, open-label study. J Clin Psychiatry. 2007 Aug;68(8):1226–9.
Gadde, Kishore M., et al. “Combination therapy of zonisamide and bupropion for weight reduction in obese women: a preliminary, randomized, open-label study.J Clin Psychiatry, vol. 68, no. 8, Aug. 2007, pp. 1226–29. Pubmed, doi:10.4088/jcp.v68n0809.
Gadde KM, Yonish GM, Foust MS, Wagner HR. Combination therapy of zonisamide and bupropion for weight reduction in obese women: a preliminary, randomized, open-label study. J Clin Psychiatry. 2007 Aug;68(8):1226–1229.

Published In

J Clin Psychiatry

DOI

EISSN

1555-2101

Publication Date

August 2007

Volume

68

Issue

8

Start / End Page

1226 / 1229

Location

United States

Related Subject Headings

  • Zonisamide
  • Weight Loss
  • Waist-Hip Ratio
  • Treatment Outcome
  • Psychiatry
  • Obesity
  • Isoxazoles
  • Humans
  • Female
  • Drug Therapy, Combination