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Treatment of blepharospasm with botulinum toxin.

Publication ,  Journal Article
Tsoy, EA; Buckley, EG; Dutton, JJ
Published in: Am J Ophthalmol
February 15, 1985

In 43 patients (81 eyes) with blepharospasm resistant to other forms of therapy, 149 outpatient injections of botulinum A toxin were given into the orbicularis oculi muscle. Subsequent follow-up periods ranged from ten to 210 days. Orbicularis oculi spasm, eyelid forced closure, and eyebrow spasm all decreased substantially over the first ten days following the initial injection. Patients with essential blepharospasm, hemifacial spasm, or previous surgery all responded in a similar fashion. This beneficial effect was transient, however, and additional treatment was required for sustained relief. Twenty-five patients received multiple injections with a mean interval of 65 days. Results of second and third injections were similar to the first in rapidity of onset and duration of effect. Complications were local, mild, and transient, and no systemic side effects were noted.

Duke Scholars

Published In

Am J Ophthalmol

DOI

ISSN

0002-9394

Publication Date

February 15, 1985

Volume

99

Issue

2

Start / End Page

176 / 179

Location

United States

Related Subject Headings

  • Ophthalmology & Optometry
  • Oculomotor Muscles
  • Middle Aged
  • Male
  • Injections, Intramuscular
  • Humans
  • Female
  • Eyelid Diseases
  • Botulinum Toxins
  • Blepharospasm
 

Citation

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Tsoy, E. A., Buckley, E. G., & Dutton, J. J. (1985). Treatment of blepharospasm with botulinum toxin. Am J Ophthalmol, 99(2), 176–179. https://doi.org/10.1016/0002-9394(85)90228-4
Tsoy, E. A., E. G. Buckley, and J. J. Dutton. “Treatment of blepharospasm with botulinum toxin.Am J Ophthalmol 99, no. 2 (February 15, 1985): 176–79. https://doi.org/10.1016/0002-9394(85)90228-4.
Tsoy EA, Buckley EG, Dutton JJ. Treatment of blepharospasm with botulinum toxin. Am J Ophthalmol. 1985 Feb 15;99(2):176–9.
Tsoy, E. A., et al. “Treatment of blepharospasm with botulinum toxin.Am J Ophthalmol, vol. 99, no. 2, Feb. 1985, pp. 176–79. Pubmed, doi:10.1016/0002-9394(85)90228-4.
Tsoy EA, Buckley EG, Dutton JJ. Treatment of blepharospasm with botulinum toxin. Am J Ophthalmol. 1985 Feb 15;99(2):176–179.
Journal cover image

Published In

Am J Ophthalmol

DOI

ISSN

0002-9394

Publication Date

February 15, 1985

Volume

99

Issue

2

Start / End Page

176 / 179

Location

United States

Related Subject Headings

  • Ophthalmology & Optometry
  • Oculomotor Muscles
  • Middle Aged
  • Male
  • Injections, Intramuscular
  • Humans
  • Female
  • Eyelid Diseases
  • Botulinum Toxins
  • Blepharospasm