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The anatomy of microbial cell state transitions in response to oxygen.

Publication ,  Journal Article
Schmid, AK; Reiss, DJ; Kaur, A; Pan, M; King, N; Van, PT; Hohmann, L; Martin, DB; Baliga, NS
Published in: Genome research
October 2007

Adjustment of physiology in response to changes in oxygen availability is critical for the survival of all organisms. However, the chronology of events and the regulatory processes that determine how and when changes in environmental oxygen tension result in an appropriate cellular response is not well understood at a systems level. Therefore, transcriptome, proteome, ATP, and growth changes were analyzed in a halophilic archaeon to generate a temporal model that describes the cellular events that drive the transition between the organism's two opposing cell states of anoxic quiescence and aerobic growth. According to this model, upon oxygen influx, an initial burst of protein synthesis precedes ATP and transcription induction, rapidly driving the cell out of anoxic quiescence, culminating in the resumption of growth. This model also suggests that quiescent cells appear to remain actively poised for energy production from a variety of different sources. Dynamic temporal analysis of relationships between transcription and translation of key genes suggests several important mechanisms for cellular sustenance under anoxia as well as specific instances of post-transcriptional regulation.

Duke Scholars

Published In

Genome research

DOI

EISSN

1549-5469

ISSN

1088-9051

Publication Date

October 2007

Volume

17

Issue

10

Start / End Page

1399 / 1413

Related Subject Headings

  • Transcription, Genetic
  • Proteome
  • Protein Biosynthesis
  • Oxygen
  • Models, Biological
  • Halobacterium salinarum
  • Energy Metabolism
  • Bioinformatics
  • Archaeal Proteins
  • Anaerobiosis
 

Citation

APA
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ICMJE
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Schmid, A. K., Reiss, D. J., Kaur, A., Pan, M., King, N., Van, P. T., … Baliga, N. S. (2007). The anatomy of microbial cell state transitions in response to oxygen. Genome Research, 17(10), 1399–1413. https://doi.org/10.1101/gr.6728007
Schmid, Amy K., David J. Reiss, Amardeep Kaur, Min Pan, Nichole King, Phu T. Van, Laura Hohmann, Daniel B. Martin, and Nitin S. Baliga. “The anatomy of microbial cell state transitions in response to oxygen.Genome Research 17, no. 10 (October 2007): 1399–1413. https://doi.org/10.1101/gr.6728007.
Schmid AK, Reiss DJ, Kaur A, Pan M, King N, Van PT, et al. The anatomy of microbial cell state transitions in response to oxygen. Genome research. 2007 Oct;17(10):1399–413.
Schmid, Amy K., et al. “The anatomy of microbial cell state transitions in response to oxygen.Genome Research, vol. 17, no. 10, Oct. 2007, pp. 1399–413. Epmc, doi:10.1101/gr.6728007.
Schmid AK, Reiss DJ, Kaur A, Pan M, King N, Van PT, Hohmann L, Martin DB, Baliga NS. The anatomy of microbial cell state transitions in response to oxygen. Genome research. 2007 Oct;17(10):1399–1413.

Published In

Genome research

DOI

EISSN

1549-5469

ISSN

1088-9051

Publication Date

October 2007

Volume

17

Issue

10

Start / End Page

1399 / 1413

Related Subject Headings

  • Transcription, Genetic
  • Proteome
  • Protein Biosynthesis
  • Oxygen
  • Models, Biological
  • Halobacterium salinarum
  • Energy Metabolism
  • Bioinformatics
  • Archaeal Proteins
  • Anaerobiosis