Scholars@Duke publication: Ciliary neurotrophic factor receptor alpha mRNA in NB41A3 neuroblastoma cells: regulation by cAMP.

Ciliary neurotrophic factor receptor alpha mRNA in NB41A3 neuroblastoma cells: regulation by cAMP.

Publication , Journal Article

MacLennan, AJ; Gaskin, AA; Vinson, EN; Martinez, LC

Published in: Eur J Pharmacol

January 4, 1996

Ciliary neurotrophic factor (CNTF) affects the in vitro and in vivo survival and differentiation of several classes of neurons by binding to the CNTF receptor alpha. We examined the possibility that intracellular cAMP can regulate CNTF receptor alpha mRNA levels in two neuronal cell lines that display cAMP-dependent process outgrowth. Dibutyryl cAMP did not affect CNTF receptor alpha mRNA levels in PC12 cells but elicited a dose- and time-dependent increase in NB41A3 cell CNTF receptor alpha mRNA levels. Forskolin similarly increased CNTF receptor alpha mRNA levels in NB41A3 cells. The data suggest that signal transduction mechanisms involving cAMP may 'crosstalk' with CNTF-initiated signal transduction in a cell type-specific manner and that CNTF receptor alpha expression is not generally linked to neuronal process outgrowth.

Duke Scholars

Author Emily Nicole Vinson Radiology, Musculoskeletal Imaging

Published In

Eur J Pharmacol

DOI

10.1016/0014-2999(95)00622-2

ISSN

0014-2999

Publication Date

January 4, 1996

Volume

295

Issue

Start / End Page

103 / 108

Location

Netherlands

Related Subject Headings

RNA, Messenger
Pharmacology & Pharmacy
Neuroblastoma
Nerve Tissue Proteins
Mice, Inbred Strains
Mice
Cyclic AMP
Colforsin
Ciliary Neurotrophic Factor
Cells, Cultured

Citation

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Chicago

ICMJE

MLA

NLM

MacLennan, A. J., Gaskin, A. A., Vinson, E. N., & Martinez, L. C. (1996). Ciliary neurotrophic factor receptor alpha mRNA in NB41A3 neuroblastoma cells: regulation by cAMP. Eur J Pharmacol, 295(1), 103–108. https://doi.org/10.1016/0014-2999(95)00622-2

MacLennan, A. J., A. A. Gaskin, E. N. Vinson, and L. C. Martinez. “Ciliary neurotrophic factor receptor alpha mRNA in NB41A3 neuroblastoma cells: regulation by cAMP.” Eur J Pharmacol 295, no. 1 (January 4, 1996): 103–8. https://doi.org/10.1016/0014-2999(95)00622-2.

MacLennan AJ, Gaskin AA, Vinson EN, Martinez LC. Ciliary neurotrophic factor receptor alpha mRNA in NB41A3 neuroblastoma cells: regulation by cAMP. Eur J Pharmacol. 1996 Jan 4;295(1):103–8.

MacLennan, A. J., et al. “Ciliary neurotrophic factor receptor alpha mRNA in NB41A3 neuroblastoma cells: regulation by cAMP.” Eur J Pharmacol, vol. 295, no. 1, Jan. 1996, pp. 103–08. Pubmed, doi:10.1016/0014-2999(95)00622-2.

MacLennan AJ, Gaskin AA, Vinson EN, Martinez LC. Ciliary neurotrophic factor receptor alpha mRNA in NB41A3 neuroblastoma cells: regulation by cAMP. Eur J Pharmacol. 1996 Jan 4;295(1):103–108.