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Environmental factors in the etiology of rhabdomyosarcoma in childhood.

Publication ,  Journal Article
Grufferman, S; Wang, HH; DeLong, ER; Kimm, SY; Delzell, ES; Falletta, JM
Published in: J Natl Cancer Inst
January 1982

In a case-control study of childhood rhabdomyosarcoma (RMS), families of 33 cases and 99 controls were interviewed. A relative risk (RR) of 3.9 was found associated with fathers' (but not mothers') cigarette smoking (P = 0.003). Cases had had fewer immunizations than controls, particularly smallpox vaccination (RR = 0.2; P = 0.001), and conversely had more preventable infections. An RR of 3.2 (P = 0.03) was found associated with exposure to chemicals and and RR of 3.7 (P = 0.004) was found associated with diets that included organ meats. Mothers of cases were more likely to be over age 30 years at subject's birth, to have used antibiotics preceding or during pregnancy, and to have had an overdue and/or assisted delivery. Other findings suggest that low socioeconomic status is associated with an increased risk of RMS. These aggregate findings imply that environmental factors may play an important role in the etiology of childhood RMS.

Duke Scholars

Published In

J Natl Cancer Inst

ISSN

0027-8874

Publication Date

January 1982

Volume

68

Issue

1

Start / End Page

107 / 113

Location

United States

Related Subject Headings

  • Socioeconomic Factors
  • Smoke
  • Risk
  • Rhabdomyosarcoma
  • Pregnancy
  • Oncology & Carcinogenesis
  • North Carolina
  • Medical History Taking
  • Maternal Age
  • Male
 

Citation

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Grufferman, S., Wang, H. H., DeLong, E. R., Kimm, S. Y., Delzell, E. S., & Falletta, J. M. (1982). Environmental factors in the etiology of rhabdomyosarcoma in childhood. J Natl Cancer Inst, 68(1), 107–113.
Grufferman, S., H. H. Wang, E. R. DeLong, S. Y. Kimm, E. S. Delzell, and J. M. Falletta. “Environmental factors in the etiology of rhabdomyosarcoma in childhood.J Natl Cancer Inst 68, no. 1 (January 1982): 107–13.
Grufferman S, Wang HH, DeLong ER, Kimm SY, Delzell ES, Falletta JM. Environmental factors in the etiology of rhabdomyosarcoma in childhood. J Natl Cancer Inst. 1982 Jan;68(1):107–13.
Grufferman, S., et al. “Environmental factors in the etiology of rhabdomyosarcoma in childhood.J Natl Cancer Inst, vol. 68, no. 1, Jan. 1982, pp. 107–13.
Grufferman S, Wang HH, DeLong ER, Kimm SY, Delzell ES, Falletta JM. Environmental factors in the etiology of rhabdomyosarcoma in childhood. J Natl Cancer Inst. 1982 Jan;68(1):107–113.
Journal cover image

Published In

J Natl Cancer Inst

ISSN

0027-8874

Publication Date

January 1982

Volume

68

Issue

1

Start / End Page

107 / 113

Location

United States

Related Subject Headings

  • Socioeconomic Factors
  • Smoke
  • Risk
  • Rhabdomyosarcoma
  • Pregnancy
  • Oncology & Carcinogenesis
  • North Carolina
  • Medical History Taking
  • Maternal Age
  • Male