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I-131, I-123, and F-18 FDG-PET imaging in a patient with diffuse sclerosing variant of papillary thyroid cancer.

Publication ,  Journal Article
Wong, TZ; Jain, MK; Spratt, SE
Published in: Clin Nucl Med
December 2008

PURPOSE: To compare the sensitivity of I-123 total body iodine (TBI) scan, I-131 TBI, and PET scanning with 2-deoxy-2[F-18]fluoro-D-glucose (FDG-PET) scans for detection of residual/recurrent disease in patients with diffuse sclerosing variant of papillary thyroid cancer. MATERIALS: A 45-year-old woman with status post-thyroidectomy and modified neck dissection showed papillary thyroid carcinoma with a diffuse sclerosing variant and positive lymph nodes. Six weeks after surgery, I-131 TBI and FDG-PET scans showed no residual or metastatic disease. However, clinical suspicion for disease remained, and an I-123 TBI scan was performed. RESULTS: I-123 TBI showed a tiny residual focus in the left thyroid bed. The patient was treated with 150 mCi oral I-131 sodium iodide; posttreatment scan confirmed the presence of residual disease. Follow-up I-123 TBI scans up to 2 1/2 years posttreatment were negative. CONCLUSION: Total body imaging with I-123 was more sensitive than I-131 TBI scanning for detecting residual or recurrent disease in patients with well-differentiated thyroid cancer presenting with low preoperative thyroglobulin levels.

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Published In

Clin Nucl Med

DOI

EISSN

1536-0229

Publication Date

December 2008

Volume

33

Issue

12

Start / End Page

834 / 837

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Thyroid Neoplasms
  • Positron-Emission Tomography
  • Nuclear Medicine & Medical Imaging
  • Neoplasm, Residual
  • Neoplasm Metastasis
  • Middle Aged
  • Iodine Radioisotopes
  • Humans
  • Fluorodeoxyglucose F18
 

Citation

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Wong, T. Z., Jain, M. K., & Spratt, S. E. (2008). I-131, I-123, and F-18 FDG-PET imaging in a patient with diffuse sclerosing variant of papillary thyroid cancer. Clin Nucl Med, 33(12), 834–837. https://doi.org/10.1097/RLU.0b013e31818bf135
Wong, Terence Z., Manoj K. Jain, and Susan E. Spratt. “I-131, I-123, and F-18 FDG-PET imaging in a patient with diffuse sclerosing variant of papillary thyroid cancer.Clin Nucl Med 33, no. 12 (December 2008): 834–37. https://doi.org/10.1097/RLU.0b013e31818bf135.
Wong, Terence Z., et al. “I-131, I-123, and F-18 FDG-PET imaging in a patient with diffuse sclerosing variant of papillary thyroid cancer.Clin Nucl Med, vol. 33, no. 12, Dec. 2008, pp. 834–37. Pubmed, doi:10.1097/RLU.0b013e31818bf135.

Published In

Clin Nucl Med

DOI

EISSN

1536-0229

Publication Date

December 2008

Volume

33

Issue

12

Start / End Page

834 / 837

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Thyroid Neoplasms
  • Positron-Emission Tomography
  • Nuclear Medicine & Medical Imaging
  • Neoplasm, Residual
  • Neoplasm Metastasis
  • Middle Aged
  • Iodine Radioisotopes
  • Humans
  • Fluorodeoxyglucose F18