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Digital tomosynthesis of the chest for lung nodule detection: interim sensitivity results from an ongoing NIH-sponsored trial.

Publication ,  Journal Article
James, TD; McAdams, HP; Song, J-W; Li, CM; Godfrey, DJ; DeLong, DM; Paik, S-H; Martinez-Jimenez, S
Published in: Med Phys
June 2008

The authors report interim clinical results from an ongoing NIH-sponsored trial to evaluate digital chest tomosynthesis for improving detectability of small lung nodules. Twenty-one patients undergoing computed tomography (CT) to follow up lung nodules were consented and enrolled to receive an additional digital PA chest radiograph and digital tomosynthesis exam. Tomosynthesis was performed with a commercial CsI/a-Si flat-panel detector and a custom-built tube mover. Seventy-one images were acquired in 11 s, reconstructed with the matrix inversion tomosynthesis algorithm at 5-mm plane spacing, and then averaged (seven planes) to reduce noise and low-contrast artifacts. Total exposure for tomosynthesis imaging was equivalent to that of 11 digital PA radiographs (comparable to a typical screen-film lateral radiograph or two digital lateral radiographs). CT scans (1.25-mm section thickness) were reviewed to confirm presence and location of nodules. Three chest radiologists independently reviewed tomosynthesis images and PA chest radiographs to confirm visualization of nodules identified by CT. Nodules were scored as: definitely visible, uncertain, or not visible. 175 nodules (diameter range 3.5-25.5 mm) were seen by CT and grouped according to size: < 5, 5-10, and > 10 mm. When considering as true positives only nodules that were scored definitely visible, sensitivities for all nodules by tomosynthesis and PA radiography were 70% (+/- 5%) and 22% (+/- 4%), respectively, (p < 0.0001). Digital tomosynthesis showed significantly improved sensitivity of detection of known small lung nodules in all three size groups, when compared to PA chest radiography.

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Published In

Med Phys

DOI

ISSN

0094-2405

Publication Date

June 2008

Volume

35

Issue

6

Start / End Page

2554 / 2557

Location

United States

Related Subject Headings

  • United States
  • Tomography
  • Sensitivity and Specificity
  • Radiography, Thoracic
  • Radiographic Image Enhancement
  • Nuclear Medicine & Medical Imaging
  • National Institutes of Health (U.S.)
  • Lung
  • Humans
  • Cohort Studies
 

Citation

APA
Chicago
ICMJE
MLA
NLM
James, T. D., McAdams, H. P., Song, J.-W., Li, C. M., Godfrey, D. J., DeLong, D. M., … Martinez-Jimenez, S. (2008). Digital tomosynthesis of the chest for lung nodule detection: interim sensitivity results from an ongoing NIH-sponsored trial. Med Phys, 35(6), 2554–2557. https://doi.org/10.1118/1.2937277
James, T Dobbins, H Page McAdams, Jae-Woo Song, Christina M. Li, Devon J. Godfrey, David M. DeLong, Sang-Hyun Paik, and Santiago Martinez-Jimenez. “Digital tomosynthesis of the chest for lung nodule detection: interim sensitivity results from an ongoing NIH-sponsored trial.Med Phys 35, no. 6 (June 2008): 2554–57. https://doi.org/10.1118/1.2937277.
James TD, McAdams HP, Song J-W, Li CM, Godfrey DJ, DeLong DM, et al. Digital tomosynthesis of the chest for lung nodule detection: interim sensitivity results from an ongoing NIH-sponsored trial. Med Phys. 2008 Jun;35(6):2554–7.
James, T. Dobbins, et al. “Digital tomosynthesis of the chest for lung nodule detection: interim sensitivity results from an ongoing NIH-sponsored trial.Med Phys, vol. 35, no. 6, June 2008, pp. 2554–57. Pubmed, doi:10.1118/1.2937277.
James TD, McAdams HP, Song J-W, Li CM, Godfrey DJ, DeLong DM, Paik S-H, Martinez-Jimenez S. Digital tomosynthesis of the chest for lung nodule detection: interim sensitivity results from an ongoing NIH-sponsored trial. Med Phys. 2008 Jun;35(6):2554–2557.

Published In

Med Phys

DOI

ISSN

0094-2405

Publication Date

June 2008

Volume

35

Issue

6

Start / End Page

2554 / 2557

Location

United States

Related Subject Headings

  • United States
  • Tomography
  • Sensitivity and Specificity
  • Radiography, Thoracic
  • Radiographic Image Enhancement
  • Nuclear Medicine & Medical Imaging
  • National Institutes of Health (U.S.)
  • Lung
  • Humans
  • Cohort Studies