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Analysis of association at single nucleotide polymorphisms in the APOE region.

Publication ,  Journal Article
Martin, ER; Gilbert, JR; Lai, EH; Riley, J; Rogala, AR; Slotterbeck, BD; Sipe, CA; Grubber, JM; Warren, LL; Conneally, PM; Saunders, AM ...
Published in: Genomics
January 1, 2000

The discussion of the prospects of using a dense map of single nucleotide polymorphisms (SNPs) to identify disease genes with association analysis has been extensive. However, there is little empiric evidence to support this strategy. To begin to examine the practical issues surrounding this methodology, we identified 10 SNPs in the region immediately surrounding the apolipoprotein E locus (APOE), an established susceptibility gene for Alzheimer disease. Our goal was to examine patterns of allelic association to begin to investigate the question of whether APOE could have been identified using SNPs. Our strongest evidence of association was at the 2 SNPs immediately flanking APOE.

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Published In

Genomics

DOI

ISSN

0888-7543

Publication Date

January 1, 2000

Volume

63

Issue

1

Start / End Page

7 / 12

Location

United States

Related Subject Headings

  • Sequence Analysis, DNA
  • Polymorphism, Single Nucleotide
  • Polymerase Chain Reaction
  • Middle Aged
  • Male
  • Humans
  • Genotype
  • Genetics & Heredity
  • Genetic Markers
  • Genetic Linkage
 

Citation

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Martin, E. R., Gilbert, J. R., Lai, E. H., Riley, J., Rogala, A. R., Slotterbeck, B. D., … Vance, J. M. (2000). Analysis of association at single nucleotide polymorphisms in the APOE region. Genomics, 63(1), 7–12. https://doi.org/10.1006/geno.1999.6057
Martin, E. R., J. R. Gilbert, E. H. Lai, J. Riley, A. R. Rogala, B. D. Slotterbeck, C. A. Sipe, et al. “Analysis of association at single nucleotide polymorphisms in the APOE region.Genomics 63, no. 1 (January 1, 2000): 7–12. https://doi.org/10.1006/geno.1999.6057.
Martin ER, Gilbert JR, Lai EH, Riley J, Rogala AR, Slotterbeck BD, et al. Analysis of association at single nucleotide polymorphisms in the APOE region. Genomics. 2000 Jan 1;63(1):7–12.
Martin, E. R., et al. “Analysis of association at single nucleotide polymorphisms in the APOE region.Genomics, vol. 63, no. 1, Jan. 2000, pp. 7–12. Pubmed, doi:10.1006/geno.1999.6057.
Martin ER, Gilbert JR, Lai EH, Riley J, Rogala AR, Slotterbeck BD, Sipe CA, Grubber JM, Warren LL, Conneally PM, Saunders AM, Schmechel DE, Purvis I, Pericak-Vance MA, Roses AD, Vance JM. Analysis of association at single nucleotide polymorphisms in the APOE region. Genomics. 2000 Jan 1;63(1):7–12.
Journal cover image

Published In

Genomics

DOI

ISSN

0888-7543

Publication Date

January 1, 2000

Volume

63

Issue

1

Start / End Page

7 / 12

Location

United States

Related Subject Headings

  • Sequence Analysis, DNA
  • Polymorphism, Single Nucleotide
  • Polymerase Chain Reaction
  • Middle Aged
  • Male
  • Humans
  • Genotype
  • Genetics & Heredity
  • Genetic Markers
  • Genetic Linkage