Skip to main content

Binding of IgG to amyloid beta A4 peptide via the heavy-chain hinge region with preservation of antigen binding.

Publication ,  Journal Article
Huang, D; Martin, M; Hu, D; Roses, AD; Goldgaber, D; Strittmatter, WJ
Published in: J Neuroimmunol
1993

Amyloid beta A4 peptide is found in the extracellular region of the senile plaque and in the angiopathy of Alzheimer's disease. Several other proteins, including IgG, also reside in these abnormal structures. In an attempt to understand how these structures are assembled and to determine how proteins are recruited, interactions of various proteins with synthetic beta A4 peptide have been examined in vitro. Purified IgG binds directly to synthetic beta A4 peptide with high avidity. The domain between amino acids 12-28 of beta A4 binds IgG. beta A4 peptide binds the hinge region of the immunoglobulin heavy chain, and preserves the ability of the immunoglobulin to bind antigen. A protein which does not bind directly to beta A4 peptide can be targetted to the senile plaque and angiopathy by binding to IgG, which avidly binds beta A4 peptide.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Neuroimmunol

DOI

ISSN

0165-5728

Publication Date

1993

Volume

48

Issue

2

Start / End Page

199 / 203

Location

Netherlands

Related Subject Headings

  • Neurology & Neurosurgery
  • Immunoglobulin Heavy Chains
  • Immunoglobulin G
  • Humans
  • Binding Sites
  • Amyloid beta-Peptides
  • 3209 Neurosciences
  • 3204 Immunology
  • 1109 Neurosciences
  • 1107 Immunology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Huang, D., Martin, M., Hu, D., Roses, A. D., Goldgaber, D., & Strittmatter, W. J. (1993). Binding of IgG to amyloid beta A4 peptide via the heavy-chain hinge region with preservation of antigen binding. J Neuroimmunol, 48(2), 199–203. https://doi.org/10.1016/0165-5728(93)90192-2
Huang, D., M. Martin, D. Hu, A. D. Roses, D. Goldgaber, and W. J. Strittmatter. “Binding of IgG to amyloid beta A4 peptide via the heavy-chain hinge region with preservation of antigen binding.J Neuroimmunol 48, no. 2 (1993): 199–203. https://doi.org/10.1016/0165-5728(93)90192-2.
Huang D, Martin M, Hu D, Roses AD, Goldgaber D, Strittmatter WJ. Binding of IgG to amyloid beta A4 peptide via the heavy-chain hinge region with preservation of antigen binding. J Neuroimmunol. 1993;48(2):199–203.
Huang, D., et al. “Binding of IgG to amyloid beta A4 peptide via the heavy-chain hinge region with preservation of antigen binding.J Neuroimmunol, vol. 48, no. 2, 1993, pp. 199–203. Pubmed, doi:10.1016/0165-5728(93)90192-2.
Huang D, Martin M, Hu D, Roses AD, Goldgaber D, Strittmatter WJ. Binding of IgG to amyloid beta A4 peptide via the heavy-chain hinge region with preservation of antigen binding. J Neuroimmunol. 1993;48(2):199–203.

Published In

J Neuroimmunol

DOI

ISSN

0165-5728

Publication Date

1993

Volume

48

Issue

2

Start / End Page

199 / 203

Location

Netherlands

Related Subject Headings

  • Neurology & Neurosurgery
  • Immunoglobulin Heavy Chains
  • Immunoglobulin G
  • Humans
  • Binding Sites
  • Amyloid beta-Peptides
  • 3209 Neurosciences
  • 3204 Immunology
  • 1109 Neurosciences
  • 1107 Immunology