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Apolipoprotein E and the CNS response to injury.

Publication ,  Journal Article
Laskowitz, DT; Horsburgh, K; Roses, AD
Published in: J Cereb Blood Flow Metab
May 1998

Apolipoprotein E (apoE) is a multifunctional protein with an expanding role in the neurobiology of disease. Although originally described in the context of cholesterol metabolism, interest in the neurobiology of apoE has intensified following the association between apoE genotype and risk of developing Alzheimer's disease. Recent clinical observations also suggest that apoE genotype may influence recovery after a variety of neurological insults. Thus, in addition to the study of disease-specific mechanisms by which apoE may modulate susceptibility of developing Alzheimer's disease, there has been an increasing focus on its role in modulating the CNS response to acute injury. Although the neurobiology of apoE in the injured brain remains incompletely defined, there is evidence to suggest neurotrophic, immunomodulatory, and antioxidant effects.

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Published In

J Cereb Blood Flow Metab

DOI

ISSN

0271-678X

Publication Date

May 1998

Volume

18

Issue

5

Start / End Page

465 / 471

Location

United States

Related Subject Headings

  • Neurology & Neurosurgery
  • Mice, Transgenic
  • Mice
  • Humans
  • Central Nervous System
  • Apolipoproteins E
  • Animals
  • Alzheimer Disease
  • 3209 Neurosciences
  • 3202 Clinical sciences
 

Citation

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Laskowitz, D. T., Horsburgh, K., & Roses, A. D. (1998). Apolipoprotein E and the CNS response to injury. J Cereb Blood Flow Metab, 18(5), 465–471. https://doi.org/10.1097/00004647-199805000-00001
Laskowitz, D. T., K. Horsburgh, and A. D. Roses. “Apolipoprotein E and the CNS response to injury.J Cereb Blood Flow Metab 18, no. 5 (May 1998): 465–71. https://doi.org/10.1097/00004647-199805000-00001.
Laskowitz DT, Horsburgh K, Roses AD. Apolipoprotein E and the CNS response to injury. J Cereb Blood Flow Metab. 1998 May;18(5):465–71.
Laskowitz, D. T., et al. “Apolipoprotein E and the CNS response to injury.J Cereb Blood Flow Metab, vol. 18, no. 5, May 1998, pp. 465–71. Pubmed, doi:10.1097/00004647-199805000-00001.
Laskowitz DT, Horsburgh K, Roses AD. Apolipoprotein E and the CNS response to injury. J Cereb Blood Flow Metab. 1998 May;18(5):465–471.
Journal cover image

Published In

J Cereb Blood Flow Metab

DOI

ISSN

0271-678X

Publication Date

May 1998

Volume

18

Issue

5

Start / End Page

465 / 471

Location

United States

Related Subject Headings

  • Neurology & Neurosurgery
  • Mice, Transgenic
  • Mice
  • Humans
  • Central Nervous System
  • Apolipoproteins E
  • Animals
  • Alzheimer Disease
  • 3209 Neurosciences
  • 3202 Clinical sciences