Association between bleomycin hydrolase and Alzheimer's disease in caucasians.
Publication
, Journal Article
Farrer, LA; Abraham, CR; Haines, JL; Rogaeva, EA; Song, Y; McGraw, WT; Brindle, N; Premkumar, S; Scott, WK; Yamaoka, LH; Saunders, AM ...
Published in: Ann Neurol
November 1998
A recent study showed modest evidence for an increased frequency of the bleomycin hydrolase (BH) V/V genotype in Alzheimer's disease (AD) patients compared with non-demented controls. To test this hypothesis, we examined this polymorphism in 621 rigorously evaluated patients and 502 control subjects (all caucasian) but were unable to detect an association between BH and AD even after controlling for age, gender, and apolipoprotein E (ApoE) genotype. We conclude that this polymorphism does not account for inherited susceptibility to AD in the populations represented in this sample.
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Published In
Ann Neurol
DOI
ISSN
0364-5134
Publication Date
November 1998
Volume
44
Issue
5
Start / End Page
808 / 811
Location
United States
Related Subject Headings
- White People
- Reference Values
- Polymorphism, Genetic
- North Carolina
- Neurology & Neurosurgery
- Male
- Humans
- Genotype
- Gene Frequency
- Female
Citation
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Chicago
ICMJE
MLA
NLM
Farrer, L. A., Abraham, C. R., Haines, J. L., Rogaeva, E. A., Song, Y., McGraw, W. T., … St George-Hyslop, P. H. (1998). Association between bleomycin hydrolase and Alzheimer's disease in caucasians. Ann Neurol, 44(5), 808–811. https://doi.org/10.1002/ana.410440515
Farrer, L. A., C. R. Abraham, J. L. Haines, E. A. Rogaeva, Y. Song, W. T. McGraw, N. Brindle, et al. “Association between bleomycin hydrolase and Alzheimer's disease in caucasians.” Ann Neurol 44, no. 5 (November 1998): 808–11. https://doi.org/10.1002/ana.410440515.
Farrer LA, Abraham CR, Haines JL, Rogaeva EA, Song Y, McGraw WT, et al. Association between bleomycin hydrolase and Alzheimer's disease in caucasians. Ann Neurol. 1998 Nov;44(5):808–11.
Farrer, L. A., et al. “Association between bleomycin hydrolase and Alzheimer's disease in caucasians.” Ann Neurol, vol. 44, no. 5, Nov. 1998, pp. 808–11. Pubmed, doi:10.1002/ana.410440515.
Farrer LA, Abraham CR, Haines JL, Rogaeva EA, Song Y, McGraw WT, Brindle N, Premkumar S, Scott WK, Yamaoka LH, Saunders AM, Roses AD, Auerbach SA, Sorbi S, Duara R, Pericak-Vance MA, St George-Hyslop PH. Association between bleomycin hydrolase and Alzheimer's disease in caucasians. Ann Neurol. 1998 Nov;44(5):808–811.
Published In
Ann Neurol
DOI
ISSN
0364-5134
Publication Date
November 1998
Volume
44
Issue
5
Start / End Page
808 / 811
Location
United States
Related Subject Headings
- White People
- Reference Values
- Polymorphism, Genetic
- North Carolina
- Neurology & Neurosurgery
- Male
- Humans
- Genotype
- Gene Frequency
- Female