
Direct effects of corticotropin-releasing hormone and thyrotropin-releasing hormone on fetal lung explants.
Publication
, Journal Article
Emanuel, RL; Torday, JS; Asokananthan, N; Sunday, ME
Published in: Peptides
December 2000
Fetal lung produces corticotropin-releasing hormone (CRH) without known direct effects. We tested the hypothesis that CRH can directly regulate lung development. In baboon fetal lung explants, CRH strongly induces surfactant phospholipid synthesis and SP-C immunostaining, plus [(3)H]thymidine incorporation. CRH receptor mRNA was detected in lung from multiple baboons at e125. Testing thyrotropin (TRH) as a specificity control, we did demonstrate different direct effects with only modest stimulation of surfactant phospholipid synthesis and strong induction of cytidylyltransferase gene expression. Therefore, CRH, similar to ACTH and glucocorticoids, is a potent inducer of cell differentiation in fetal lung.
Duke Scholars
Published In
Peptides
DOI
ISSN
0196-9781
Publication Date
December 2000
Volume
21
Issue
12
Start / End Page
1819 / 1829
Location
United States
Related Subject Headings
- Time Factors
- Thyrotropin-Releasing Hormone
- Thymidine
- Surface-Active Agents
- Reverse Transcriptase Polymerase Chain Reaction
- RNA, Messenger
- Proliferating Cell Nuclear Antigen
- Phospholipids
- Peroxidase
- Papio
Citation
APA
Chicago
ICMJE
MLA
NLM
Emanuel, R. L., Torday, J. S., Asokananthan, N., & Sunday, M. E. (2000). Direct effects of corticotropin-releasing hormone and thyrotropin-releasing hormone on fetal lung explants. Peptides, 21(12), 1819–1829. https://doi.org/10.1016/s0196-9781(00)00343-0
Emanuel, R. L., J. S. Torday, N. Asokananthan, and M. E. Sunday. “Direct effects of corticotropin-releasing hormone and thyrotropin-releasing hormone on fetal lung explants.” Peptides 21, no. 12 (December 2000): 1819–29. https://doi.org/10.1016/s0196-9781(00)00343-0.
Emanuel RL, Torday JS, Asokananthan N, Sunday ME. Direct effects of corticotropin-releasing hormone and thyrotropin-releasing hormone on fetal lung explants. Peptides. 2000 Dec;21(12):1819–29.
Emanuel, R. L., et al. “Direct effects of corticotropin-releasing hormone and thyrotropin-releasing hormone on fetal lung explants.” Peptides, vol. 21, no. 12, Dec. 2000, pp. 1819–29. Pubmed, doi:10.1016/s0196-9781(00)00343-0.
Emanuel RL, Torday JS, Asokananthan N, Sunday ME. Direct effects of corticotropin-releasing hormone and thyrotropin-releasing hormone on fetal lung explants. Peptides. 2000 Dec;21(12):1819–1829.

Published In
Peptides
DOI
ISSN
0196-9781
Publication Date
December 2000
Volume
21
Issue
12
Start / End Page
1819 / 1829
Location
United States
Related Subject Headings
- Time Factors
- Thyrotropin-Releasing Hormone
- Thymidine
- Surface-Active Agents
- Reverse Transcriptase Polymerase Chain Reaction
- RNA, Messenger
- Proliferating Cell Nuclear Antigen
- Phospholipids
- Peroxidase
- Papio