Skip to main content

Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl.

Publication ,  Journal Article
Sunday, ME; Weinberger, JZ; Benacerraf, B; Dorf, ME
Published in: J Immunol
October 1980

The primary anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibody response is known to have a heteroclitic fine specificity, i.e., anti-NP antibodies bind (4-hydroxy-5-iodo-3-nitrophenyl)acetyl (NIP) with greater affinity than NP itself. Past studies of NP-specific DTH responses and NP-specific T cell-mediated suppression have demonstrated sharing of fine specificity patterns and idiotypic structure between receptors on NP-specific T cells and anti-NP antibodies. We now analyze the fine specificity of NP-specific cutaneous sensitivity (CS) reactions to NP-O-succinimide (NP-O-Su) and NIP-O-succinimide (NIP-O-Su). The specificity of these responses is shown to be controlled by genes in the Igh gene complex. Cross-reactive CS responses induced by NP-O-Su elicited by NIP-O-Su were observed in strains of mice possessing the Igh-1b allotype but not in strains bearing the Igh-1c or Igh-1j allotypes. The CS reactivity could be adoptively transferred to naive recipients, and the ability of transfer CS reactivity was T cell dependent. In contrast to the genetic requirement for I-A region homology to adoptively transfer DTH reactions, compatibility at either the H-2K, H-21, or H-2D regions was sufficient to transfer NP-specific CS reactivity to naive recipients. Furthermore, in contrast to DTH responses, cyclophosphamide pretreatment was not required to induce CS responsiveness. Thus, the specificity of NP-O-Su-induced CS responses is controlled by both H-2- and Igh-linked genes.

Duke Scholars

Published In

J Immunol

ISSN

0022-1767

Publication Date

October 1980

Volume

125

Issue

4

Start / End Page

1601 / 1605

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Succinimides
  • Phenylacetates
  • Nitrophenols
  • Mice, Inbred DBA
  • Mice, Inbred C57BL
  • Mice, Inbred C3H
  • Mice
  • Kinetics
  • Immunology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sunday, M. E., Weinberger, J. Z., Benacerraf, B., & Dorf, M. E. (1980). Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. J Immunol, 125(4), 1601–1605.
Sunday, M. E., J. Z. Weinberger, B. Benacerraf, and M. E. Dorf. “Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl.J Immunol 125, no. 4 (October 1980): 1601–5.
Sunday ME, Weinberger JZ, Benacerraf B, Dorf ME. Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. J Immunol. 1980 Oct;125(4):1601–5.
Sunday, M. E., et al. “Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl.J Immunol, vol. 125, no. 4, Oct. 1980, pp. 1601–05.
Sunday ME, Weinberger JZ, Benacerraf B, Dorf ME. Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. J Immunol. 1980 Oct;125(4):1601–1605.

Published In

J Immunol

ISSN

0022-1767

Publication Date

October 1980

Volume

125

Issue

4

Start / End Page

1601 / 1605

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Succinimides
  • Phenylacetates
  • Nitrophenols
  • Mice, Inbred DBA
  • Mice, Inbred C57BL
  • Mice, Inbred C3H
  • Mice
  • Kinetics
  • Immunology