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Anti-receptor antibody-induced suppression of murine H-Y-specific delayed-type hypersensitivity responses.

Publication ,  Journal Article
Sunday, ME; Weinberger, JZ; Wolff, S; Dorf, ME
Published in: Eur J Immunol
August 1981

A putative anti-H-Y receptor antiserum (ARA) was raised in C57BL/6 male mice against splenic T lymphocytes from syngeneic females immunized against H-Y antigen. When this antiserum is given i.v. to C57BL/6 females it prevents the expression of H-Y-specific delayed-type hypersensitivity (DTH). The suppressive activity in ARA was selectively retained on rabbit anti-mouse immunoglobulin columns, and could be absorbed by H-Y-immune spleen cells from C57BL/6 female mice. The abrogation of H-Y DTH reactivity was at least in part due to the generation of suppressor T cells which are generated by ARA in naive female mice. ARA-generated suppressor cells specifically inhibit the induction phase of DTH responses to the H-Y antigen, having no effect on (4-hydroxy-3-nitrophenyl)acetyl (NP)-specific cutaneous sensitivity responses or on DTH responses to minor histocompatibility antigens. Furthermore, there is a requirement for Igh gene homology between the strain producing the ARA and the strain in which the DTH response is induced. Thus, C57BL/6 ARA given to A.BY (H-2b, Igh-1e) or to B.C-8 (H-2b, Igh-1a) mice was unable to suppress homologous H-Y DTH responses in these strains. However, C57BL/6 ARA induced suppressor cells in B.C-8 mice which were capable of inhibiting H-Y DTH responses when adoptively transferred to C57BL/6 females.

Duke Scholars

Published In

Eur J Immunol

DOI

ISSN

0014-2980

Publication Date

August 1981

Volume

11

Issue

8

Start / End Page

626 / 631

Location

Germany

Related Subject Headings

  • Y Chromosome
  • T-Lymphocytes, Regulatory
  • T-Lymphocytes
  • Spleen
  • Sex Chromosomes
  • Receptors, Immunologic
  • Rabbits
  • Mice, Inbred C57BL
  • Mice, Inbred BALB C
  • Mice, Inbred A
 

Citation

APA
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MLA
NLM
Sunday, M. E., Weinberger, J. Z., Wolff, S., & Dorf, M. E. (1981). Anti-receptor antibody-induced suppression of murine H-Y-specific delayed-type hypersensitivity responses. Eur J Immunol, 11(8), 626–631. https://doi.org/10.1002/eji.1830110807
Sunday, M. E., J. Z. Weinberger, S. Wolff, and M. E. Dorf. “Anti-receptor antibody-induced suppression of murine H-Y-specific delayed-type hypersensitivity responses.Eur J Immunol 11, no. 8 (August 1981): 626–31. https://doi.org/10.1002/eji.1830110807.
Sunday ME, Weinberger JZ, Wolff S, Dorf ME. Anti-receptor antibody-induced suppression of murine H-Y-specific delayed-type hypersensitivity responses. Eur J Immunol. 1981 Aug;11(8):626–31.
Sunday, M. E., et al. “Anti-receptor antibody-induced suppression of murine H-Y-specific delayed-type hypersensitivity responses.Eur J Immunol, vol. 11, no. 8, Aug. 1981, pp. 626–31. Pubmed, doi:10.1002/eji.1830110807.
Sunday ME, Weinberger JZ, Wolff S, Dorf ME. Anti-receptor antibody-induced suppression of murine H-Y-specific delayed-type hypersensitivity responses. Eur J Immunol. 1981 Aug;11(8):626–631.
Journal cover image

Published In

Eur J Immunol

DOI

ISSN

0014-2980

Publication Date

August 1981

Volume

11

Issue

8

Start / End Page

626 / 631

Location

Germany

Related Subject Headings

  • Y Chromosome
  • T-Lymphocytes, Regulatory
  • T-Lymphocytes
  • Spleen
  • Sex Chromosomes
  • Receptors, Immunologic
  • Rabbits
  • Mice, Inbred C57BL
  • Mice, Inbred BALB C
  • Mice, Inbred A