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Angiogenesis in non-small cell lung cancer.

Publication ,  Journal Article
D'Amico, TA
Published in: Semin Thorac Cardiovasc Surg
2004

Two processes are necessary for a tumor colony to grow and become invasive: angiogenesis and basement membrane degradation. Angiogenesis is the formation of new blood vessels from the endothelium of existing vasculature, in response to the metabolic demand of the tumor. Assessment of the degree of tumor angiogenesis may improve risk stratification in patients with lung cancer, especially those with early-stage disease. In addition, the strategy of blocking the mechanism of angiogenesis may prove to be an effective therapeutic alternative for patients with nonsmall cell lung cancer. Clinical trials evaluating novel antiangiogenic agents, including antibodies to vascular endothelial growth factor (VEGF) and compounds directed at the tyrosine kinase receptor, are ongoing.

Duke Scholars

Published In

Semin Thorac Cardiovasc Surg

DOI

ISSN

1043-0679

Publication Date

2004

Volume

16

Issue

1

Start / End Page

13 / 18

Location

United States

Related Subject Headings

  • United States
  • Respiratory System
  • Neovascularization, Pathologic
  • Neoplasm Metastasis
  • Lung Neoplasms
  • Lung
  • Humans
  • Carcinoma, Non-Small-Cell Lung
  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology
 

Citation

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Chicago
ICMJE
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D’Amico, T. A. (2004). Angiogenesis in non-small cell lung cancer. Semin Thorac Cardiovasc Surg, 16(1), 13–18. https://doi.org/10.1053/j.semtcvs.2004.01.003
D’Amico, Thomas A. “Angiogenesis in non-small cell lung cancer.Semin Thorac Cardiovasc Surg 16, no. 1 (2004): 13–18. https://doi.org/10.1053/j.semtcvs.2004.01.003.
D’Amico TA. Angiogenesis in non-small cell lung cancer. Semin Thorac Cardiovasc Surg. 2004;16(1):13–8.
D’Amico, Thomas A. “Angiogenesis in non-small cell lung cancer.Semin Thorac Cardiovasc Surg, vol. 16, no. 1, 2004, pp. 13–18. Pubmed, doi:10.1053/j.semtcvs.2004.01.003.
D’Amico TA. Angiogenesis in non-small cell lung cancer. Semin Thorac Cardiovasc Surg. 2004;16(1):13–18.
Journal cover image

Published In

Semin Thorac Cardiovasc Surg

DOI

ISSN

1043-0679

Publication Date

2004

Volume

16

Issue

1

Start / End Page

13 / 18

Location

United States

Related Subject Headings

  • United States
  • Respiratory System
  • Neovascularization, Pathologic
  • Neoplasm Metastasis
  • Lung Neoplasms
  • Lung
  • Humans
  • Carcinoma, Non-Small-Cell Lung
  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology